5-溴-7-氮杂吲哚的合成工艺研究  

Study on synthesis of 5-bromo-7-azaindole

作　　者：李铮铮[1] 龙飞飞[1] 施海风 滕大为[1] 

机构地区：[1]青岛科技大学化工学院,山东青岛266042

出　　处：《应用化工》2014年第8期1470-1472,共3页Applied Chemical Industry

摘　　要：以7-氮杂吲哚为原料,经氢化还原、溴化和脱氢等三步反应,制备了5-溴-7-氮杂吲哚;研究了氢化还原和溴化反应的工艺条件。较佳工艺条件:1氢化还原,反应压力为4 MPa,反应温度为95℃,反应时间12 h,溴化,7-氮杂吲哚啉和溴素的摩尔比为1∶1.15,总收率74.7%。5-Bromo-7-azaindole has been synthesized by the hydride reduction,bromination,and dehydro-genation of 7-azaindole. The conditions on hydride reduction and bromination reaction was studied,and obtained the optimal process conditions：the hydrogen reduction reaction pressure was 4 MPa and tempera-ture was 95℃,the reaction time was 12 h,the molar ratio of n（7-azaindole）：n（bromine）=1：1. 15. The total yield as high as 74 . 7%.

关 键 词：5-溴-7-氮杂吲哚 7-氮杂吲哚 7-氮杂吲哚啉 溴素 

分 类 号：TQ251.3[化学工程—有机化工]