病毒性心肌炎患者血清IL17、IL35水平变化及意义  

Expression and clinical significance of interleukin-17 and interleukin-35 in the serum of patients with viral moycarditis

作　　者：张传峰 苑海涛[2] 

机构地区：[1]临清市人民医院,山东临清252600 [2]山东大学附属省立医院

出　　处：《山东医药》2014年第31期28-30,共3页Shandong Medical Journal

基　　金：国家自然科学基金资助项目(81070188)

摘　　要：目的观察病毒性心肌炎(VMC)患者血清IL-17、IL-35水平变化,探讨其意义。方法选择70例VMC患者(VMC组,其中急性期41例、恢复期29例)及30例健康查体者(对照组),采用ELISA法检测血清IL-17、IL-35水平,采用微粒子化学发光免疫分析法检测心肌肌钙蛋白I(cTnI)水平,分析各指标相关性。结果 VMC组血清IL-17及cTnI水平均显著高于对照组、血清IL-35水平显著低于对照组,尤以急性期为著(P均<0.05)。VMC组血清IL-17和IL-35分别与cTnI水平呈正相关、负相关,r值分别为0.681、-0.583,P均<0.05;血清IL-17与IL-35水平呈负相关,r=-0.482,P<0.01。结论 VMC患者血清IL-17与IL-35水平异常并与病情有关,两者可能共同参与了VMC的发生、发展。Objective To investigate the expression and its clinical significance of serum interleukin -17 （ IL-17 ） and interleukin-35（IL-35） in patients with viral moycarditis （VMC）.Methods Seventy patients with VMC（VMC group, 41 in acute stage and 29 in remission stage ） and 30 healthy subjects （ control group ） were enrolled , Enzyme-linked immu-nosorbent assay（ELISA） was used to detect the blood serum level of IL-17 and IL-35, and chemiluminescent microparticle immunoassa was used to detect the blood serum level of cardiac troponin I （cTnI）.The relationship among the indexes were analyzed.Results The serum level of IL-17 and cTnI in VMC group were both higher than those in the control group ,and the IL-35 was in the contrary, especially for the patients in acute stage （ all P〈0.05）.The serum level of IL-17 and IL-35 showed positive and negative corelation to the cTnI , r=0.681,-0.583（ both P〈0.05）;IL-17 was negatively correlated to IL-35,r=-0.482,P〈0.01.Conclusion The blood serum level of IL-17 and IL-35 in VMC patients is abnormal and correlated to the codition , these two indexes may be involved in the pathogenesis and development of VMC .

关 键 词：病毒性疾病 心肌炎 白细胞介素-17 白细胞介素-35 

分 类 号：R542.2[医药卫生—心血管疾病]