再生纤维素/胶原蛋白复合伤口敷料的制备及其性能评价  

The preparation of regenerated cellulose/collagen composite wound dressing and its performance evaluation

作　　者：陆金婷 程咏梅[1] 赵朋[2] 吕国忠[2] 陈敬华[1] 

机构地区：[1]江南大学药学院,江苏无锡214122 [2]南通大学第三附属医院,江苏无锡214041

出　　处：《功能材料》2014年第14期14150-14155,共6页Journal of Functional Materials

基　　金：国家自然科学基金资助项目(81272106;21306066);教育部博士点基金资助项目(20110093110008);江苏省自然科学基金资助项目(BK2012557;BK2012543)

摘　　要：用高碘酸钠将再生纤维素膜(RC)部分氧化,得到具有醛基的2,3-二醛纤维素膜(DARC,醛基含量为6.11%),再通过席夫碱反应将胶原蛋白固定到DARC膜上,制备得到DARC-Col复合敷料。SEM结果显示DARC-Col复合敷料具有多孔网络结构。该材料具有良好的机械性能(拉伸强度78.09MPa,断裂伸长率9.59%),溶胀性能(182%),透湿性(703.72g/m2·d)和保水性(20%)。NIH-3T3小鼠成纤维细胞实验结果表明,该材料能有效促进细胞的生长和增殖,具有作为理想的伤口敷料应用于伤口修复治疗的巨大潜能。In this study,an approach to prepare regenerated cellulose/collagen composite dressing was pro-posed.Firstly,regenerated cellulose membrane was oxidized by periodate oxidation for the preparation of 2,3-dialdehyde cellulose （DARC,the dialdehyde content was 6 .1 1%）,and then it was reacted with collagen to ob-tain the target DARC-Col composite dressing by Schiff base reaction.The scanning electron microscopy re-vealed that DARC-Col composite dressing exhibited the refined network structures.In addition,the composite dressing showed novel mechanical properties （the strain was 78.09 MPa,the stress was 9.59%）,good equilib-rium-swelling ratio （182%）,good air permeability （703.72 g/m2 ＆#183;d）and excellent water retaining property （20%）.Furthermore,the test of NIH3T3 mice fibroblast cells indicated that DARC-Col could promote cell growth and proliferation.The DARC-Col composite dressing showed great potential as ideal wound dressing for the wound repair application.

关 键 词：再生纤维素 胶原蛋白 复合伤口敷料 

分 类 号：Q539.3[生物学—生物化学] O629.73[理学—有机化学]