MGF-Ct24E功能化聚乳酸仿生骨基质材料的制备与表征  

Synthesis and characterization of MGF-Ct24E functional bionic bone matrix materials of polylactic acid

作　　者：彭坤[1,2] 孙姣霞[3] 李玉筱[1] 张兵兵[1] 王远亮[1] 甘晓玲[2] 王易振[2] 

机构地区：[1]重庆大学生物工程学院生物材料与仿生工程研究中心,重庆400030 [2]重庆医药高等专科学校医学技术学院,重庆401331 [3]重庆交通大学河海学院,重庆400074

出　　处：《功能材料》2014年第14期14156-14160,共5页Journal of Functional Materials

基　　金：国家自然科学基金资助项目(30870609);重庆市教委资助项目(KJ112501);重庆市卫生局资助项目(2012-2-257)

摘　　要：以羟基磷灰石(HAP)表面羟基为引发基团,通过开环聚合法将丙交酯以共价化学键的方式接枝到HAP表面,得到PLA-g-HAP;再引入具有良好细胞相容性的马来酸酐和具有良好骨诱导性的力生长因子(MGF-Ct24E),得到MGF-Ct24E-MPLA-g-HAP。借助红外光谱分析、氨基酸分析、热性能分析、力学性能分析和电镜分析,对上述材料的结构及性能进行了表征。结果表明,最终产物中MGF-Ct24E的接枝率为22.63%,玻璃化转变温度为58.62℃,力学性能有明显增强,并具备了三维互通孔状结构和骨诱导生物活性。该材料有望作为新型仿生骨基质材料得到应用。Biomimetic bone matrix materials was a kind of scaffold material which could be induction of bone seed cells transplantation and promotion of the growth of new bone,should have good properties of biodegrad-ability,biocompatibility,mechanical strength and osteoinduction.Based on the preliminary research of the bio-mimetic bone matrix materials of polylactic acid （PLA）,prepared covalent chemical bonds grafted PLA-g-HAP with initiation of surface hydroxyl groups of hydroxyapatite （HAP）and ring-opening polymerization of lactide, and prepared MGF-Ct24E-MPLA-g-HAP with introduction of maleic anhydride with good cell compatibility and growth factor （MGF-Ct24E）with good osteoinduction.The structure and properties of materials had been characterized by infrared spectrum analysis,amino acid analysis,thermal performance analysis,mechanical per-formance analysis and electron microscopy （SEM）analysis.Results show that the final product with the 3D pore structure and biological activity of osteoinduction,which MGF-Ct24E grafting was 22.63%,glass transi-tion temperature was 58.62 ℃,mechanical properties have obvious enhancement.Therefore,the material was expected to be applied as a new type of bionic bone matrix materials.

关 键 词：仿生骨基质材料 聚乳酸 MGF-Ct24E 羟基磷灰石 化学接枝 

分 类 号：TB324[一般工业技术—材料科学与工程] R318.08[医药卫生—生物医学工程]