不同孕期妇女尿液甲状腺功能相关激素含量变化  

Content change of urinary thyroid hormone parameters during pregnancy

作　　者：蔡佳 张曼[1] 赵旭宏[1] 雷婷[1] 孟倩[1] 周慧[1] 

机构地区：[1]首都医科大学附属北京世纪坛医院检验科,北京100038

出　　处：《重庆医学》2014年第24期3124-3126,共3页Chongqing medicine

基　　金：国家科技支撑计划项目(2013BAI12B01-4)

摘　　要：目的分析妊娠期妇女尿液甲状腺功能相关激素含量的变化,为进一步研究通过检测尿液监测其甲状腺功能状态奠定基础。方法随机选择30名健康产科门诊志愿者,孕9～12周起直至分娩,每4周收集1次各孕妇的随机尿标本。电化学发光免疫分析法测定尿促甲状腺激素(uTSH)、尿游离三碘甲状腺原氨酸(uFT3)和尿游离甲状腺素(uFT4),酶免疫分析法测定尿视黄醇结合蛋白(uRBP)浓度。经uRBP校正后,统计分析孕期uTSH与uRBP比值(uTSH/uRBP)、uFT3与uRBP比值(uFT3/uRBP)和uFT4与uRBP比值(uFT4/uRBP)的含量变化。结果该研究得到各妊娠时段尿液中甲状腺功能相关激素的中值浓度。统计学分析表明,各妊娠时段孕妇uFT3/uRBP和uFT4/uRBP含量比较差异均有统计学意义(F=6.222,P<0.05;F=5.078,P<0.05),且呈线性趋势变化(F=27.480,P<0.05;F=23.959,P<0.05)。uTSH/uRBP的含量在各妊娠时段差异无统计学意义(F=2.731,P=0.054)。结论经uRBP校正后,健康孕妇各妊娠时段uFT3和uFT4的含量呈线性趋势下降,uTSH的含量无明显变化趋势。Objective To further research the urinary monitoring of the maternal thyroid functional status ,the levels of urine thyroid hormones were analyzed during pregnancy .Methods This study recruited 30 cases of healthy pregnant women at 9-12 ges-tational weeks .Their random urine specimens were collected every four weeks until delivery .The concentrations of urine thyrotro-pin（uTSH） ,urine free triiodothyronine（uFT3） and urine free tetraiodothyronine（uFT4） were detected by electrochemical lumines-cence immunoassay（ECLIA） .The urine retinol binding protein（uRBP） was detected by enzyme immunoassay （EIA） .After correc-ted by uRBP ,the statistical analysis was done to analyze the variation of the ratio of uTSH and uRBP （uTSH/uRBP） ,the ratio of uFT3 and uRBP（uFT3/uRBP）and the ratio of uFT4 and uRBP（uFT4/uRBP）during pregnancy .Results The median levels of u-rine thyroid hormone parameters were obtained from the healthy pregnant women every four weeks and were compared among dif-ferent stages .The difference of uFT3/uRBP and uFT4/uRBP was statistically significant （F= 6 .222 ,P〈 0 .05 ;F= 5 .078 ,P〈0 .05） ,and the levels of them varied linearity during pregnancy （F=27 .480 ,P〈0 .05 ;F=23 .959 ,P〈0 .05） .The difference of uT-SH/uRBP had no statistical significance（F=2 .731 ,P=0 .054） .Conclusion After corrected by uRBP ,the levels of uFT3 and uFT4 of healthy pregnant women decreased linearity among different gestational stages ,and the levels of uTSH had no noticeable change .

关 键 词：妊娠 尿液分析 促甲状腺激素 游离三碘甲状腺原氨酸 游离甲状腺素 

分 类 号：R446.12[医药卫生—诊断学]