结肠靶向给药制备技术的研究进展  

Progress in preparation techniques of colon-specific drug delivery system

作　　者：詹璐璐[1,2] 尹东东[2] 王杏林[2] 王转[2] 

机构地区：[1]河南大学药学院,开封475001 [2]天津药物研究院释药技术与药代动力学国家重点实验室,天津300193

出　　处：《中国新药杂志》2014年第16期1868-1874,共7页Chinese Journal of New Drugs

基　　金：国家"重大新药创制"科技重大专项(2014ZX09507005-002)

摘　　要：结肠因具有特殊的生理环境而特别适于作为某些特殊疾病和药物治疗的靶向器官。近年,结肠靶向给药系统在制剂学和靶向材料研究等方面取得了较大进展。口服结肠靶向给药系统的制备技术主要可分为生物黏附技术、前体药物技术、包衣技术、胶囊化技术、微粒技术、骨架技术等。本文综述了结肠靶向给药制备技术的最新研究进展,以期为结肠靶向给药制剂的制备提供参考。Colon can be used as the target organ for treating certain specific diseases for its special physiological environment. In recent years, great progress had been made in colon-specific drug delivery system, focused on pharmaceutics and targeted materials. The preparation techniques of oral colon-specific drug delivery system include bio-adhesion technology, pro-drug technology, coating methods, encapsulation methods, microencapsulation technique and matrix technology. This article reviewed the latest research on preparation technology of colon targeted drug delivery system, which could provide reference for preparing colon targeted drug delivery formulations.

关 键 词：结肠靶向给药 生物黏附技术 前体药物技术 包衣技术 胶囊化技术 

分 类 号：R943[医药卫生—药剂学]