新生儿病理性黄疸患儿红细胞葡萄糖-6-磷酸脱氢酶活性检测的临床意义  

Clinical significance of erythrocyte glucose-6-phosphate dehydrogenase activity detection in pathological jaundice of neonate

作　　者：张黎霞 邹洪兴 李永祥[2] 周贞[2] 

机构地区：[1]嘉兴市第一医院检验科,浙江嘉兴314000 [2]嘉兴市妇幼保健院检验科,浙江嘉兴314000

出　　处：《检验医学》2014年第7期730-732,共3页Laboratory Medicine

摘　　要：目的探讨新生儿病理性黄疸患儿葡萄糖-6-磷酸脱氢酶(G6PD)活性检测的临床意义。方法检测200例新生儿病理性黄疸患儿(简称黄疸组)和100名健康新生儿(正常对照组)G6PD活性并做比较。依据G6PD缺乏判断标准(<2.5 U/L)将200例新生儿病理性黄疸患儿分为G6PD缺乏组和无G6PD缺乏组,比较两组之间的胆红素浓度和G6PD活性。结果黄疸组胆红素浓度明显高于正常对照组(P<0.05),而G6PD活性明显低于对照组(P<0.05)。G6PD缺乏组胆红素浓度明显高于无G6PD缺乏组(P<0.05)。结论 G6PD缺乏是新生儿病理性黄疸发生的重要原因。加强对新生儿G6PD的监测可以为临床预防和治疗新生儿病理性黄疸提供依据。Objective To investigate the clinical significance of erythrocyte glucose-6-phosphate dehydrogenase（ G6PD） activity detection in pathological jaundice of neonate. Methods A total of 200 cases of neonatal pathological jaundice（ jaundice group） and 100 healthy newborns（ control group） were enrolled and detected for G6 PD activity,and the results were compared. On the basis of G6 PD deficiency judgment standard（ 2. 5 U /L）,200 cases of neonatal pathological jaundice were classified into G6 PD deficiency group and non G6 PD deficiency group. The comparison of bilirubin concentration and G6 PD activity between the 2 groups was performed. Results The concentration of bilirubin in jaundice group was significantly higher than that in control group（ P 0. 05）,but the G6 PD activity in jaundice group was significantly lower than that in control group（ P 0. 05）. In G6 PD deficiency group,bilirubin concentration was higher than that in non G6 PD deficiency group（ P 0. 05）. Conclusions G6 PD deficiency is an important cause of neonatal pathological jaundice. Strengthening the monitoring of neonatal G6 PD can provide the reference for clinical prevention and treatment of neonatal pathological jaundice.

关 键 词：葡萄糖-6-磷酸脱氢酶 病理性黄疸 新生儿 

分 类 号：Q554[生物学—生物化学]