β-内酰胺类致白细胞减少患者的临床分析  

Analysis of leucopenia in patients treated with β-lactam antibiotics

作　　者：张兴[1] 米佳丽[2] 尹怀文 李钟勇[2] 顾平[2] 袁琳[2] 

机构地区：[1]遂宁市中心医院普外科,四川遂宁629000 [2]遂宁市中心医院药剂科,四川遂宁629000

出　　处：《实用药物与临床》2014年第8期1041-1043,共3页Practical Pharmacy and Clinical Remedies

基　　金：遂宁市科技局项目(201202)

摘　　要：目的评价两种治疗方案对白细胞减少患者再次使用抗感染药物临床特点的影响,以优化治疗方案,提高临床用药水平。方法收集某三甲医院收治的所有转归后再次使用抗感染药物治疗的病例共70例,将其分为β-内酰胺类组和其他抗感染药物组,比较两组间患者血清白细胞计数、C-反应蛋白、血肌酐、尿素、ALT、AST情况。结果β-内酰胺组和其他抗菌药物组患者的白细胞计数、C-反应蛋白、尿素比较差异无统计学意义,而血肌酐、ALT、AST比较差异有统计学意义(P<0.05)。结论对β-内酰胺类抗菌药物导致白细胞减少的患者,转归后仍使用该类药物疗效显著。Objective To assess the influence of two kinds of treatment protocols on leucopenia patients who were treated with β-1actam antibiotics on the clinical manifestations, so as to optimize and improve the medication. Methods Seventy leucopenia patients treated with β-1actam antibiotics again were selected, and divided into two groups with or without β-1actam antibiotics. All patients＇levels of white blood cells, C-reactive protein, serum creatinine, urea nitrogen, alanine aminotransferase and aspartate aminotransferase were compared. Results The patients with β-1actam antibiotics were similarly higher in levels of white blood cells, C-reactive protein, urea nitrogen than those with other antibiotics. There was significant difference in serum creatinine, alanine aminotransferase and aspartate aminotransferase between the two groups （ P 〈 0. 05 ）. Conclusion The β-1actam antibiotics have large clinical significance in patients treated with β-lactam antibiotics again.

关 键 词：白细胞减少 Β-内酰胺类 临床特点 分析 

分 类 号：R557.1[医药卫生—血液循环系统疾病]