半乳糖凝集素3在乳腺癌中的表达及与人表皮生长因子受体2的关系  

The expression of Galectin-3 and its relationship with human epidermal growth factor receptor 2 in breast cancer

作　　者：袁媛[1] 张耀龙[2] 范宏娟 宋旭东[4] 于增荣 

机构地区：[1]河北省唐山市妇幼保健院普外科,063000 [2]河北省唐山市协和医院急诊科,063000 [3]山西省介休市人民医院急诊科,032000 [4]河北联合大学基础医学院病理科,河北唐山063000

出　　处：《蚌埠医学院学报》2014年第7期846-848,共3页Journal of Bengbu Medical College

摘　　要：目的:研究半乳糖凝集素3(Galectin-3)在乳腺浸润性导管癌中的表达情况,探讨其与乳腺癌临床病理参数及人表皮生长因子受体2(Her-2)之间的关系。方法:收集70例乳腺浸润性导管癌组织,采用免疫组织化学法检测标本中Galectin-3、Her-2表达水平,对于Her-2 2+的组织进行荧光原位杂交检测。分析Galectin-3的表达与患者年龄、肿瘤大小、淋巴结转移情况、组织学分级、临床分期及Her-2的关系。结果:在不同年龄及肿瘤大小的乳腺癌组织中Galectin-3阳性率差异均无统计学意义(P>0.05)。淋巴结阳性组Galectin-3的阳性率高于淋巴结阴性组(P<0.05);在不同组织分化程度及临床分期间Galectin-3的阳性率差异均有统计学意义(P<0.05)。乳腺癌组织中Galectin-3阳性率高于Her-2阳性率(P<0.05)。结论:Galectin-3在乳腺癌的发生、发展、侵袭和转移过程中发挥重要作用。检测乳腺癌组织中Galectin-3表达情况,有助于对肿瘤恶性程度及预后的判断,可能成为指导临床治疗的靶向指标之一。Objective：To detect the expression of Galactose lectin 3 （Galectin-3） and its relationship with clinicopathological features and human epidermal growth factor receptor-2 （Her-2） in breast infiltrating ductal carcinoma.Methods：The expression levels of Galectin-3 and Her-2 in 70 breast infiltrating ductal carcinoma tissue samples were detected by immunohistochemical method.The Her-2 gene expression was detected by fluorescence in situ hybridization.The relationships between the expression of Galectin-3 with the patient age,tumor size,lymph node metastasis,histological grade,clinical stage and Her-2 expression were investigated.Results：The positive rate differences of Galectin-3 expression in different age and tumor size breast cancer tissue had no statistically significant（P ＞ 0.05）.The positive rate of Galectin-3 expression in sample with lymph node metastasis was higher than that in sample without metastasis（P＜ 0.05）.The positive rate differences of Galectin-3 expression in different histological grade and clinical stage had statistically significant（P ＜ 0.05）.The positive rate of Galectin-3 expression was higher than Her-2 expression in breast cancer tissue （P ＜ 0.05）.Conclusions：Galectin-3 plays an important role in the occurrence,development,invasion and metastasis of breast cancer.Detecting the expression of Galectin-3 in breast cancer can contribute to judge the malignant degree and prognosis of tumor,which maybe become an important index in guiding clinical treatment.

关 键 词：乳腺肿瘤 半乳糖凝集素3 受体 表皮生长因子 病理学 临床 

分 类 号：R737.9[医药卫生—肿瘤]