非肥胖型与肥胖型多囊卵巢综合征的临床生化特征比较  

Comparison of the clinical and biochemical features of non-obese and obese women with polycystic ovary syndrome

作　　者：周晓燕[1] 吴霞[1] 张琦[1] 

机构地区：[1]皖北煤电集团总医院生殖医学科,安徽宿州234000

出　　处：《蚌埠医学院学报》2014年第7期855-857,共3页Journal of Bengbu Medical College

基　　金：蚌埠医学院科研资助课题(Byky1269NF)

摘　　要：目的：探讨非肥胖型多囊卵巢综合征（PCOS）患者的临床生化特征.方法：将81例PCOS患者根据体质量指数（BMI）分为非肥胖组（BMI＜ 25 kg/m2）和肥胖组（BMI ≥25 kg/m2）,比较2组患者临床与生化特征.结果：非肥胖组月经正常率为24.49％,肥胖组为5.9％;非肥胖组闭经率8.5％,肥胖组为26.5％;2组月经类型差异有统计学意义（P＜0.05）;非肥胖组PCOS患者卵泡刺激素（FSH）、黄体生成素（LH）、LH/FSH、高密度脂蛋白均高于肥胖组（P＜0.05～P＜0.01）;总睾酮、空腹血糖、空腹胰岛素、总胆固醇、三酰甘油和低密度脂蛋白均低于肥胖组（P ＜0.05 ～P＜0.01）.结论：非肥胖的PCOS患者主要表现为下丘脑-垂体-卵巢轴功能紊乱,而肥胖的PCOS患者主要表为现胰岛素抵抗及血脂紊乱,临床诊治应个体化.Objective：To investigate the clinical and biochemical features of non-obese polycystic ovary syndrome （PCOS） patients.Methods：According to the body mass index （BMI）,the 81 patients with PCOS were divided into the non-obese group （BMI ＜ 25 kg/ m2） and obese group（BMI ≥25 kg/m2）,the clinical and biochemical features between two groups were compared.Results：The normal menstruation and amenorrhea rates in non-obese group and obese group were 24.49％ ＆ 5.9％ and 8.5％ ＆ 26.5％,respectively,the differences of which were statistical significance （P ＜ 0.05）.The levels of the follicle stimulating hormone （FSH）,luteinizing hormone （LH）,ratio of LH to FSH and high density lipoprotein cholesterol in non-obese group were higher than those in obese group（P ＜0.05 to P ＜ 0.01）,the levels of the fasting plasma glucose,fasting insulin,total cholesterol,triglyceride and low density lipoprotein in non-obese group were significantly lower than those in obese group（P ＜ 0.05 to P ＜ 0.01）.Conclusions：The non-obese PCOS patients are characterized by the dysfunction of hypothalamus-pituitary gland-ovary axis,the obese PCOS patients are characterized by the dysfunction of metabolism disorder of blood lipid and insulin resistance.The clinical diagnosis and treatment should be individualized.

关 键 词：多囊卵巢综合征 体质量指数 胰岛素抵抗 

分 类 号：R711.75[医药卫生—妇产科学]