血清β-HCG、hsCRP和Npt水平与足月胎膜早破孕妇羊膜感染的相关性研究  

Study on the correlation between serum β- hCG,hsCRP and Npt levels and intra amniotic infection in pregnant women with premature rupture of fetal membrane

作　　者：厉波[1] 王金柱[1] 陈红[1] 

机构地区：[1]山东省临沂市人民医院临床检验中心,276003

出　　处：《中国妇幼保健》2014年第25期4066-4069,共4页Maternal and Child Health Care of China

摘　　要：目的:探讨血清绒毛膜促性腺激素(β-HCG)、高敏C-反应蛋白(hsCRP)及新蝶呤(Npt)在足月胎膜早破孕妇中的诊断价值及其与羊膜腔感染的关系。方法:选取行剖宫产分娩的185例足月胎膜早破孕妇为研究对象(观察组),另选取同期行剖宫产分娩的180例正常孕妇为对照组,采用放射免疫法测定两组Npt水平,化学发光法测定β-HCG、免疫散射比浊法测定hsCRP。结果:与对照组相比,观察组血清β-HCG、hsCRP、Npt水平显著升高,差异有统计学意义(P<0.05)。与轻、中度羊膜腔感染相比,重度羊膜腔感染血清β-HCG、hsCRP、Npt水平显著升高,差异有统计学意义(P<0.05)。经受试者工作特征曲线(ROC)分析可知,β-HCG+hsCRP+Npt联合检测羊膜腔感染敏感性、特异性高于β-HCG、hsCRP、Npt单一诊断,差异有统计学意义(P<0.05)。结论:血清β-HCG、hsCRP、Npt水平可作为足月胎膜早破孕妇羊膜腔感染的预测指标,三者联合诊断可提高诊断敏感性及特异性。Objective： To explore the diagnostic values of serum β- human chorionic gonadotropin （ β- HCG）, high sensitive C -reactive protein （hsCRP） and neopterin （Npt） and their relationships with intraamniotic infection. Methods： A total of full -term 185 pregnant women with premature rupture of fetal membrane （PROM） adopting cesarean section in the hospital were selected as study objects （observation group） , 180 normal pregnant women adopting cesarean section during the same period were selected as control group; radioimmunoassay was used to detect the levels of serum Npt in the two groups, chemiluminescence was used to detect the levels of serum β- HCG in the two groups, and immunological scatting turbidity method was used to detect the levels of hsCRP in the two groups. Results ： Compared with control group, the levels of serum β- hCG, hsCRP and Npt in. observation group increased, there were statistically significant differences （P 〈 0. 05 ） . Compared with patients with mild and moderate intraamniotic infection, the levels of serum β- hCG, hsCRP and Npt in patients with severe intraamniotie infection increased, there were statistically significant differences （ P 〈 0. 05 ） . ROC curve showed that the sensitivity and specificity of joint detection of β- HCG ＋ hsCRP ＋ Npt were statistically significantly higher than those of single detection of β- HCG, hsCRP and Npt （ P 〈 0. 05 ） . Conclusion ： Serum β- hCG, hsCRP and Npt levels can be used as predictors of intraamniotic infection in pregnant women with PROM, joint detection of β- HCG ＋ hsCRP ＋ Npt can improve the diagnostic sensitivity and specificity.

关 键 词：绒毛膜促性腺激素 C -反应蛋白 新蝶呤 胎膜早破 羊膜感染 

分 类 号：R714.433[医药卫生—妇产科学]