小儿急性肾炎患者血清中TNF-α、IGF-Ⅱ、GM-CSF和VEGF水平的研究  

Study on serum levels of TNF- α,IGF- Ⅱ,GM- CSF and VEGF in children with acute nephritis

作　　者：吕慧[1] 刘建忠[2] 

机构地区：[1]深圳市龙岗区妇幼保健院,518172 [2]深圳市儿童医院

出　　处：《中国妇幼保健》2014年第25期4089-4091,共3页Maternal and Child Health Care of China

摘　　要：目的:探讨小儿急性肾炎患儿血清中TNF-α、IGF-Ⅱ、GM-CSF和VEGF水平变化。方法:应用放射免疫分析法与酶联双抗体夹心法测定67例小儿急性肾炎患儿治疗前、后血清TNF-α、IGF-Ⅱ、GM-CSF和VEGF水平,并与67例正常儿童血清中的TNF-α、IGF-Ⅱ、GM-CSF和VEGF水平进行比较。结果:患儿组治疗前、后TNF-α、IGF-Ⅱ、GMCSF、VEGF水平明显高于正常儿童组,差异有统计学意义(P<0.05)。急性肾炎患儿治疗前TNF-α水平与IGF-Ⅱ、GMCSF、VEGF水平呈正相关。结论:TNF-α、IGF-Ⅱ、GM-CSF和VEGF水平与小儿急性肾炎的发生、发展密切相关。Objective： To explore the changes of serum levels of tumor necrosis factor - α （TNF - α）, insulin - like growth factor - Ⅱ （ IGF - Ⅱ ）, granulocyte - macrophage colony stimulating factor （ GM - CSF） and vascular endothelial growth factor （VEGF） in children with acute nephritis. Methods ： RIA and double - antibody sandwich ELISA were used to detect serum levels of TNF - α, IGF - Ⅱ, GM - CSF and VEGF in 67 children with acute nephritis before and after treatment, then the results were compared with serum levels of TNF - α, IGF - Ⅱ , GM - CSF and VEGF in 67 normal children. Results： Serum levels of TNF - α, IGF - Ⅱ, GM -CSF and VEGF in children with acute nephritis before and after treatment were statistically significantly higher than those in normal children （ P 〈 0. 05 ） ; before treatment, serum TNF - α level was positively correlated with serum levels of IGF - Ⅱ , GM - CSF and VEGF in children with acute nephritis. Conclusion ： Serum levels of TNF - α, IGF - Ⅱ , GM - CSF and VEGF are closely correlated with occurrence and development of acute nephritis in children.

关 键 词：小儿急性肾炎 肿瘤坏死因子-α 胰岛素样生长因子-Ⅱ 巨噬细胞集落刺激因子 血管内皮生长因子 

分 类 号：R725.7[医药卫生—儿科]