扎鲁司特联合舒利迭治疗支气管哮喘患儿的疗效及对肺功能的影响  

Curative effect of Zafirlukast combined with Seretide in treatment of bronchial asthma in children and the impact on pulmonary function

作　　者：林建国[1] 陈杏桃[1] 

机构地区：[1]广东省江门市新会区人民医院儿科,529100

出　　处：《中国妇幼保健》2014年第25期4092-4094,共3页Maternal and Child Health Care of China

摘　　要：目的：探讨扎鲁司特联合舒利迭治疗儿童支气管哮喘的疗效及对肺功能的影响。方法：选取2010年6月~2013年10月江门市新会区人民医院收治的104例支气管哮喘患儿,将患儿随机分为观察组及对照组,每组各52例。在常规治疗的基础上,对照组加用舒利迭吸入治疗,观察组采取舒利迭与扎鲁司特联合治疗。评定两组患儿的治疗效果及治疗前后的肺功能情况并进行统计学分析。结果：观察组与对照组的总有效率分别为90.38%和71.16%,观察组显著高于对照组,差异有统计学意义（P〈0.05）;治疗后,观察组和对照组的1 s用力呼气容积（FEV1）（实测值∕预计值）分别为（72.83±10.77）%和（63.28±10.24）%,观察组明显高于对照组,差异有统计学意义（P〈0.05）;观察组的峰值呼气流速（PEF）（实测值∕预计值）为（69.24±9.93）%,明显高于对照组〔（59.86±10.05）%〕,差异有统计学意义（P〈0.05）。结论：舒利迭与扎鲁司特联合治疗儿童支气管哮喘在缓解临床症状、提高治疗效果及改善肺功能等方面具有显著的优越性。Objective ： To explore the curative effect of Zafirlukast combined with Seretide in treatment of bronchial asthma in children and the impact on pulmonary function. Methods： A total of 104 children with bronchial asthma treated in the hospital from June 2010 to October 2013 were selected and randomly divided into observation group and control group, 52 children in each group. Based on conventional therapy, the patients in control group were treated with inhalation therapy of Seretide, the patients in observation group were treated with combined therapy of Seretide and Zafirlukast. The curative effects and pulmonary functions before and after treatment in the two groups were assessed, and a statistical analysis was performed. Results： The total effective rates in observation group and control group were 90. 38% and 71.16% , respectively, the total effective rate in observation group was statistically significantly higher than that in control group （P 〈 0. 05 ） ; after treatment, predicted forced expiratory volumes in one second （FEV1） （measured value/expected value） in observation group and control group were （72. 83 ± 10. 77 ）% and （63.28 ± 10. 24）%, respectively, FEV1 （measured value/expected value） in observation group was statistically significantly higher than that in control group （ P 〈 0. 05 ） ; peak expiratory flow rate （PEF） （ measured value/expected value） in observation group was （69. 24 ± 9.93 ）fro, which was statistically significantly higher than that in control group [ （ 59.86 ± 10. 05 ） % ] （ P 〈 0. 05 ） . Conclusion ： Seretide combined with Zafirlukast has significant advantages of relieving clinical symptoms, improving curative effect and pulmonary function in treatment of children with bronchial asthma.

关 键 词：扎鲁司特 舒利迭 儿童 支气管哮喘 肺功能 

分 类 号：R725.6[医药卫生—儿科]