窒息新生儿心肌酶谱的分析  

Analysis on myocardial enzymes in neonates with asphyxia

作　　者：包克珍[1] 

机构地区：[1]四川省成都市新都区第二人民医院,610501

出　　处：《中国妇幼保健》2014年第25期4097-4099,共3页Maternal and Child Health Care of China

摘　　要：目的：探讨血清心肌酶活性测定在新生儿窒息中的临床应用价值,为临床早期诊断新生儿窒息提供临床依据。方法：选择2011年6月~2013年6月窒息新生儿64例,其中重度窒息22例（重度组）,轻度窒息42例（轻度组）,同期正常新生儿50例（对照组）。观察各组天门冬酸氨基转移酶（AST）、乳酸脱氢酶（LDH）、肌酶激酶（CK）、肌酸激酶同工酶（CK-MB）、α-羟丁酸脱氢酶（α-HBDH）水平。结果：重度组AST、CK、HBDH、CK-MB和LDH分别为（139.66±11.62）U/L、（958.37±50.44）U/L、（958.37±50.44）U/L、（138.06±9.82）U/L和（526.18±46.36）U/L,高于轻度组[（76.47±8.51）U/L、（410.28±17.26）U/L、（410.28±17.26）U/L、（63.71±5.09）U/L和（354.80±32.15）U/L],且重度组和轻度组均高于对照组,各组间比较,差异有统计学意义（P〈0.05）。窒息新生儿治疗1周后,AST、CK、HBDH、CK-MB和LDH分别为（65.12±5.39）U/L、（116.12±9.48）U/L、（107.84±9.83）U/L、（131.28±10.46）U/L和（201.30±17.84）U/L,均低于治疗前[（101.38±9.64）U/L、（814.52±36.19）U/L、（490.51±30.36）U/L、（815.62±56.19）U/L和（493.64±29.32）U/L],治疗前后比较,差异有统计学意义（P〈0.05）。结论：窒息新生儿心肌酶谱均升高,并可根据其升高的程度,作为辅助判定窒息程度及心肌损害的客观参考指标,并可评估患儿预后状况,以便早期诊断及时治疗。Objective： To explore the clinical application value of serum myocardial enzymes activity detection in neonates with asphyxia, and provide a clinical basis for early diagnosis of asphyxia in neonates. Methods ： Sixty - four neonates with asphyxia were selected from June 2011 to June 2013, including 22 neonates with severe asphyxia （ severe asphyxia group） and 42 neonates with mild asphyxia （ mild asphyxia group）; 50 normal neonates during the same period were selected as control group. The levels of aspartate aminotransferase （AST）, lactate dehydrogenase （LDH）, creatine kinase （CK）, ereatine kinase isoenzyme （CK- MB）, α- hydroxybutyrate dehydrogenase （α -HBDH） in the three groups were observed. Results： AST, CK, HBDH, CK - MB and LDH levels in severe asphyxia group were （ 139. 66 ± 11.62） U/L, （958.37 ±50. 44） U/L, （958. 37 ±50. 44） U/L, （138.06 ±9. 82） U/L and （526. 18 ±46. 36） U/L, respectively, which were higher than those in mild asphyxia group [ （76. 47 ± 8.51） U/L, （410. 28 ± 17.26） U/L, （410. 28 ± 17. 26） U/L, （63.71 ±5.09） U/L and （354. 80 ±32. 15） U/L, respectively] , AST, CK, HBDH, CK - MB and LDH levels in severe asphyxia group and mild asphyxia group were higher than those in control group, there were statistically significant differences among the three groups （ P 〈 0. 05） . After treatment for one week, AST, CK, HBDH, CK - MB and LDH levels in neonates with asphyxia were （65. 12 ±5.39） U/L, （ 116. 12 ± 9.48） U/L, （ 107.84 ± 9. 83 ） U/L, （ 131.28 ± 10. 46） U/L and （201.30 ± 17.84） U/L, respectively, which were lower than those before treatment [ （101.38 ±9.64） U/L, （814.52 ±36.19） U/L, （490.51 ±30.36） U/L, （815.62 ±56.19） U/L and （493.64 ±29. 32） U/L, respectively], there were statistically significant differences between before and after treatment （P 〈 0.05） . Conclusion ： Myocardial enzymes of neonates with asphyxia increase, which can be used as auxi

关 键 词：新生儿窒息 心肌酶 心肌损害 

分 类 号：R722.12[医药卫生—儿科]