尼美舒利解热镇痛抗炎作用比较研究  

Comparison of Antipyretic, Anti-analgesic and Anti-inflammatory Effects of Nimesulide in Animal Models

作　　者：岑彦艳[1] 覃容欣[1] 李小丽[1] 彭伟[1] 潘夕春[1] 蒋为薇[1] 张海港[1] 陈晓红[1] 

机构地区：[1]第三军医大学药学系药理学教研室,重庆400038

出　　处：《中国现代应用药学》2014年第8期933-938,共6页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的研究尼美舒利的解热、镇痛、抗炎作用的量效关系，比较尼美舒利3种药理作用的ED50为临床合理使用尼美舒利提供依据。方法分别采用热灭活大肠埃希菌制备家兔发热模型、冰醋酸制备小鼠疼痛模型、角叉菜胶诱发大鼠足跖肿胀模型，观察尼美舒利的解热、镇痛、抗炎作用，并计算ED。结果尼美舒利能显著降低家兔体温，减少小鼠扭体次数，明显减轻大鼠足关节肿胀程度，其解热、镇痛、抗炎作用的ED50分别为0.85～1．95，2.56，3.15～4.05mg·kg^-1，根据体表面积比例换算成人ED50分别为0．50～0.60，2.72，0.26～0.59mg·kg^-1。结论尼美舒利发挥解热、镇痛和抗炎作用的ED，n存在差异，其中解热最低。OBJECTIVE To investigate the antipyretic, analgesic and anti-inflammatory effects of nimesulide in laboratory animals, and compare the ED50 of three pharmacological activities. METHODS The antipyretic activity was evidenced by heatinactivation E. coli induced fever in rabbits; the analgesic activity was evidenced by acetic acid induced abdominal pain in mice; the anti-inflammatory activity of nimsulide was evidenced by carrageenan induced paw edema in rats. RESULTS In the antipyretic test to lower body temperature by heat inactivation E. coli induced fever, the ED50 was 0.85-1,95 mg·kg-1 within 2-6 h. In anti-analgesic studies using writhing test in mice, the ED50 was 24.56 mg·kg^-1. The ED50 of nimesulide p.o. were determined in carrageenan foot edema in rats within 1-7 h, ED50 was 3.15-4.05 mg·kg^-1. The median effective doses in animals were converted to the ED50 in human being were 0.50-0.60, 2.72, 0.26-0.59 mg·kg^-1, respectively. CONCLUSION The various pharmacological activities ED50 of nimesulide is different, the effective dose of antipyretic is the lowest.

关 键 词：尼美舒利 解热 镇痛 抗炎 半数有效量 

分 类 号：R965.2[医药卫生—药理学]