益智根茎的抗肿瘤活性成分研究  

Anti-cancer bioactive components from stem of Alpinia oxyphylla Miq

作　　者：李海龙[1,2] 魏娜[1,2] 罗喻超[1,2] 李永辉[1,2] 张俊清[1,2] 

机构地区：[1]海南医学院热带药用植物研究开发重点实验室,海南海口571101 [2]海南医学院药学院,海南海口571101

出　　处：《时珍国医国药》2014年第8期1833-1835,共3页Lishizhen Medicine and Materia Medica Research

基　　金：国家"十二五"区域基地项目子课题(No.2011BAI01B07);海南省中药现代化项目(No.2010ZY012;2011ZY004;2012ZY010);海南医学院科研培育基金(No.HY2012-006;HY2012-013)

摘　　要：目的研究益智根茎中抗肿瘤的活性成分。方法以4种肿瘤细胞PC-12、MCF-7、HepG2和Mku-45的细胞毒作用为活性筛选方法,采用MTT活性导向分离益智根茎中的抗肿瘤活性成分。结果结果发现黄酮类成分是益智根茎细胞毒的主要活性成分,其中杨芽黄素、依砂黄素、4'-甲氧基芹菜素和乔松素对4种肿瘤细胞均具有较好的抑制作用。结论首次研究了益智根茎的抗肿瘤作用,基本明确黄酮类成分是益智根茎抗肿瘤的主要活性成分。Objective To study the anti - cancer bioactive components from stem of Alpinia oxyphflla Miq. Methods The anti - cancer active components were screened using PC - 12, MCF - 7, HepG2 and Mku - 45 cell cytotoxic activity and detected by MTT. Results The flavone compounds were the main bioactivity ingredients. Four compounds, namely chrysin izalpinin 4′-methoxy - apigenin and pinocembrin, have good inhibition on the four cancer cells. Conclusion This is the first time to study the anti - cancer compounents in stem of Alpinia oxyphylla Miq. This paper clarified the flavone components were the main anti - cancer compounds in stem of Alpinia oxyphylla Miq.

关 键 词：益智根茎 抗肿瘤 活性成分 

分 类 号：R285.5[医药卫生—中药学]