定经汤对卵巢早衰模型大鼠行为学的影响  

Effect of Ding Jing Decoction on Changes of Behavior in Premature Ovarian Failure Rat Model

作　　者：邓树泳 张琰[2] 马娜[2] 邢德刚[2] 

机构地区：[1]广州王老吉药业股份有限公司,广东广州510450 [2]广东药学院,广东广州510006

出　　处：《时珍国医国药》2014年第8期2013-2015,共3页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(No.81073073)

摘　　要：目的探讨定经汤对卵巢早衰模型大鼠行为学的影响。方法用复合心理应激刺激方法建立卵巢早衰动物模型,通过大鼠动情周期、性激素水平、暗箱行为差异和液体消耗量评价模型以及观察定经汤的治疗作用。结果与正常组比较,模型组大鼠动情周期明显紊乱或延长(P﹤0.01),E2水平明显下降(P<0.01),FSH水平明显升高(P<0.05),水平运动和垂直运动明显减少(P<0.01或P<0.05),糖水消耗量和总液体消耗量也明显减少(P<0.01或P<0.05);与模型组比较,治疗组大鼠动情周期明显改善(P﹤0.05),E2水平明显升高(P<0.01),FSH水平明显降低(P<0.01),水平运动和垂直运动明显增加(P<0.05),糖水消耗量和总液体消耗量也明显增加(P<0.01)。结论心理应激法可以建立卵巢早衰大鼠模型,定经汤对卵巢早衰模型大鼠的行为有改善作用。Objective To explore the effect of Ding Jing Decoction on changes of behavior in premature ovarian failure rat model. Methods composite psychological stress stimulation methods were used to establish an animal model of premature ovarian failure. To evaluate the model and observe the therapeutic effect of ding jing tang through the rat estrous cycle, hormone levels, camera obscura behavior and liquid consumption. Results Compared with normal group, model group rat estrous cycle significantly disordered or extended （ P 〈O. O1 ）. E2 levels were significantly decreased （ P 〈0.01 ）. FSH levels were significantly increased （ P 〈0. 05 ）. Horizontal and vertical movements significantly reduced ,as so as sugar consumption and total liquid consumption（ P 〈0. 01 or P 〈 O. 05 ）, Compared with model group, treatment group rat estrous cycle significantly improved （ P 〈0.05 ）. E2 levels were significantly increased （P 〈O. O1 ）. FSH levels were significantly decreased （P 〈0. O1 ）. Horizontal and vertical movements significantly increased, as so as sugar consumption and total liquid consumption （P 〈0.01 or P 〈0.05 ）. Conclusion Premature o- varian failure rat model can be made by the method of psychological stress. Ding jing tang can effectively improve behavioral in premature ovarian failure rat model.

关 键 词：定经汤 卵巢早衰 暗箱行为 液体消耗 

分 类 号：R285.5[医药卫生—中药学]