生长激素超促排卵对卵巢反应不良患者的影响  

The effect of growth hormone in poor responders undergoing COH

作　　者：牛芳[1] 李柳铭 吴洪波[1] 

机构地区：[1]广西医科大学第一附属医院生殖中心, 广西壮族自治区南宁530000

出　　处：《中国基层医药》2014年第19期2902-2904,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的：观察重组人生长激素（GH）在行体外受精-胚胎移植（IVF-ET）超促排卵过程中，对卵巢反应不良患者治疗效果的影响。方法将行IVF/CSI治疗的80例卵巢反应不良患者按数字表法随机分为两组：加用GH的为观察组（40例），未用GH的为对照组（40例），观察其促性腺激素使用总量及天数、获卵数及成熟卵母细胞数、受精率、卵裂率、获胚胎数目、优质胚胎数以及妊娠率，并应用ELISA法检测血清胰岛素样生长因子I（IGF-I）、胰岛素样生长因子结合蛋白3（IGFBP-3）的浓度，比较其差异。结果观察组使用促性腺激素量及天数、获卵数及成熟卵母细胞数、卵裂率、获胚胎数目、优质胚胎数均对照组，但差异均无统计学意义（均P＞0.05）；两组血清IGFBP-3浓度差异无统计学意义；两组受精率、妊娠率以及血清IGF-I浓度差异均有统计学意义（均P＜0．05）。结论合用GH可改善卵巢反应不良患者IVF-ET的结局，其机制与提高血清IGF-I浓度、改善卵子质量有关。Objective To observe the efficacy of growth hormone （ GH） co-treatment in poor responders undergoing IVF-ET.Methods To analyze all the ovaries low response patients treated by IVF/ICSI,80 cases were ran-domly divided into two groups：40 patients in GH group were given GH along with Gn daily until the HCG administra-tion.40 patients in the control group received the same treatment protocol except the GH co -treatment.The catching spawn number and MⅡova,fertile rate,the number of perfect embryos ,pregnant rate were observed .The serum con-centrations of IGF-I,IGFBP-3 were detected by ELISA and compared between the two groups .Results The number of oocytes retrieved ,number of MII oocytes ,cleavage ,number of embryos available of GH group were increased without statistical significance（all P〉0.05 ）.The serum IGFBP-3 level of 2 groups had no statistical significance .The fertile rate,pregnant rate ,serum IGF-I level were significantly higher in GH group than those in the control group （ all P〈0.05）.Conclusion GH co-treatment in poor responders could improve the outcome of IVF-ET,which imply that GH could improve the quality of oocytes and embryos related to the elevated IGF-1 level in serum .

关 键 词：生长激素 体外受精 卵巢反应不良 胰岛素样生长因子结合蛋白3 

分 类 号：R714.8[医药卫生—妇产科学]