乌司他丁对重度烧伤患者炎症因子水平的影响  

The influence of ulinastatin on body inflammatory factor levels in patients with severe burns

作　　者：陈粹[1] 范友芬[1] 樊理华[2] 张淳[1] 吴天斌[1] 

机构地区：[1]宁波市第二医院烧伤科,浙江宁波315010 [2]温州医科大学附属第六医院麻醉科,浙江丽水323000

出　　处：《中国现代医生》2014年第25期32-34,共3页China Modern Doctor

基　　金：浙江省科技计划项目(2008C33036)

摘　　要：目的：研究乌司他丁对重症烧伤患者体内炎症因子水平的影响,为临床重症烧伤患者的治疗提供依据。方法对2010年1月~2013年6月我院入院治疗的94例重度烧伤患者进行了研究,分为两组,对照组给予常规治疗,包括补液、抗休克、早期切削痂手术以及营养支持等,治疗组患者在上述治疗方案基础上,加用乌司他丁,连续治疗7d,比较治疗前后两组患者血常规、体内炎症因素水平变化以及APACHE Ⅱ评分（acute physiology and chronic health evaluation,急性生理与慢性健康评分）。结果与治疗前比较,两组患者白细胞（white blood cells,WBC）、中性粒细胞数量明显降低,血小板（blood platelet,）数量明显升高,且治疗组患者改善更明显,差异有统计学意义（P〈0.05）。两组患者全身炎症反应综合征（systemic inflammatory response syndrome,SIRS）诊断时APACHE II评分基本相当,72h后有明显差异,治疗组明显低于对照组,差异有统计学意义（P〈0.05）；治疗组患者肿瘤坏死因子α（tumor necrosis factor alpha,TNF-α）和白介素-6（interleukin-6,IL-6）的水平明显低于对照组,白介素-2（interleukin-2,IL-2）和白介素-10（interleukin-10,IL-10）的水平明显高于对照组,差异有统计学意义（P〈0.05）。结论乌司他丁能够明显的改善患者体内的炎症状态,对于改善患者的症状,防止并发症的发生具有重要的意义。Objective To research the influence of ulinastatin on body inflammatory factor levels in patients with severe burns, and provide the basis treatment of patients with severe burns. Methods A total of 94 patients from Jan 2010 to June 2013 were studied in this test. The control group was treated with basic therapy including fluid infusion, antishock, cutting scab surgery and early nutrition support while the treatment group was received ulinastatin on the basic of control. Routine blood, body inflammatory factors level change and APACHE II score were compared between the two groups, Results The number of WBC and neutrophil in treatment group was higher than control 1group （P 〈0.05）, while the PLT was lower than control group （P〈0.05）. The APACHE II score was in the same level between the two groups before treatment, while the score of treatment group was obvious lower than control control group after 72hr （P〈0.05）. The TNF-α and IL-6 in treatment group was lower than control wihle the IL-2 and IL-10 was higher than control（P〈0.05）. Conclusion Ulinastatin played an important role in improving the patient＇s body state of inflammation, the patient＇s symptom and preventing complications.

关 键 词：乌司他丁 重度烧伤 炎症因子 

分 类 号：R644[医药卫生—外科学]