化痰祛瘀汤对急性缺血性中风病患者hs-CRP、MMP-9的影响  

Influence of Huatan Quyu decoction on hs-CRP and MMP-9 in patients with acute ischemia stroke

作　　者：朱宏勋[1] 黄粤[1] 曹锐[1] 

机构地区：[1]首都医科大学附属北京朝阳医院中医科,北京100020

出　　处：《北京中医药》2014年第8期584-586,共3页Beijing Journal of Traditional Chinese Medicine

基　　金：北京市中医管理局青年科学研究资助项目(QN2010-02)

摘　　要：目的研究化痰祛瘀汤对急性缺血性中风病患者超敏C反应蛋白(hs-CRP)、基质金属蛋白酶9(MMP-9)的影响。方法纳入急性缺血性中风病痰瘀阻络证患者79例,随机分为治疗组40例,对照组共39例,对照组给予内科常规治疗,治疗组在对照组基础上加用化痰祛瘀汤,于治疗前、治疗后第6天测定患者hs-CRP、MMP-9水平,并于治疗前及治疗后第12天进行中医证候评分及神经功能缺损(NIHSS)测定。结果治疗组在治疗后第6天时即能降低hs-CRP、MMP-9水平,与对照组比较,差异有统计学意义(P<0.05)。治疗组在治疗后12天时能降低中医痰证评分,与对照组比较,差异有统计学意义(P<0.05),而血瘀证评分及NIHSS评分2组间比较差异无统计学意义(P>0.05)。结论化痰祛瘀汤能降低缺血性中风病痰瘀阻络证患者hs-CRP、MMP-9水平,通过减轻脑缺血后炎症损伤,达到治疗效果。Objective To study the influence of Human Quyu decoction on hyper-sensitive C-reactive protein （hs-CRP） and matrix metalloproteinase-9 （MMP-9） in patients with acute ischemia stroke. Methods Seventy-nine patients of acute ischemia stroke with phlegm and blood stasis obstructing meridian were included and randomly divided into a treatment group （40 cases） and a control group （39 cases）. Regular treatment was given in the control group, while based on the treatment in the control group, the Huatan Quyu decoction was additionally used in the treatment group. The level of hs-CPR and MMP-9 were measured before the treatment and 6 days into treatment; the TCM syndrome score and National Institutes of Health Stroke Scale （NIHSS） were evaluated before the treatment and 12 days into treatment. Results Six days into the treatment, the levels of hs-CPR and MMP-9 were reduced in the treatment group, which was significant compared with that in the control group （ P 〈 0. 05 ） ; 12 days into the treatment, the TCM phlegm score was reduced in the treatment group, which was significant compared with that in the control group （P 〈 0. 05 ）. However, there were no significant differences of TCM blood stasis score and NIHSS between the two groups （ P 〉 0. 05 ）. Conclusion The Huatan Quyu decoction could reduce the level of hs-CPR and MMP-9 in patients of acute ischemia stroke with phlegm and blood stasis obstructing meridian, which achieves the treatment effects by relieving inflammatory injury after cerebral ischemia.

关 键 词：化痰祛瘀汤 急性缺血性中风病 痰瘀阻络证 基质金属蛋白酶9 超敏C反应蛋白 

分 类 号：R277.7[医药卫生—中医学]