落新妇苷对斑马鱼心脑血管疾病模型的作用研究  

Effect of astilbin in zebrafish models of cerebral and cardiovascular diseases

作　　者：应军 李晶晶[2] 黎晌[2] 李铭源[2] 

机构地区：[1]广州医药研究总院有限公司,广东广州510240 [2]澳门大学中华医药研究院/中药质量研究国家重点实验室,澳门999078

出　　处：《广东药学院学报》2014年第4期472-474,共3页Academic Journal of Guangdong College of Pharmacy

基　　金：广州市对外科技合作项目(2011J5200007)

摘　　要：目的考察落新妇苷在心脑血管疾病方面的作用。方法利用斑马鱼血管新生损伤模型、斑马鱼出血性中风模型及斑马鱼心脏损伤模型考察落新妇苷在心脑血管方面的作用。结果在1 mmol/L浓度下落新妇苷恢复了血管生长因子受体酪氨酸激酶抑制剂(VRI)所诱导的血管损伤模型中新生血管的生长,在节间血管(ISV)损伤区域恢复生成了70%以上的完整血管,但对斑马鱼心脏损伤模型和斑马鱼出血性中风模型未见明显效果。结论落新妇苷对血管损伤导致的血管新生不足具有显著的治疗作用。Objective To investigate the effect of astilbin on experimental models of heart and cerebrovascular diseases. Methods Zebrafish models of blood vessel injury,hemorrhagic stroke and heart damage were used to study the cerebral and cardiovascular protective activities of astilbin. Results 1 mmol/L Astilbin rescued 70%of blood vessel loss in ISV region by VEGFR tyrosine kinase inhibitor （ VRI ）-induced blood vessel damage model,but did not show obvious effect in the zebrafish models of hemorrhagic stroke and heart damage. Conclusion Astilbin has potential vascular protective effect in the zebrafish model with deficiency of angiogenesis.

关 键 词：落新妇苷 斑马鱼模型 心脑血管疾病 

分 类 号：R285.5[医药卫生—中药学]