黄芪皂苷对慢性心衰大鼠心室重塑及血浆脑钠肽水平的影响  

Effect of astragaloside on the ventricular remodeling and plasma brain natriuretic peptide expression in rats with chronic heart failure

作　　者：黄健莹[1] 梁健健[2] 陈振宇[3] 

机构地区：[1]广州市第一人民医院鹤洞分院内科,广东广州510180 [2]广州市第一人民医院药剂科,广东广州510180 [3]广州市第一人民医院检验科,广东广州510180

出　　处：《广东药学院学报》2014年第4期479-481,共3页Academic Journal of Guangdong College of Pharmacy

摘　　要：目的探讨黄芪皂苷对慢性心衰大鼠心室重塑及血浆脑钠肽水平的影响。方法利用结扎左冠状动脉前降支复制心梗后心衰大鼠模型,造模成功后随机分为模型组、黄芪皂苷低、高剂量组(10、20 mg/kg)。假手术组仅冠状动脉前降支下穿线不结扎。每组15只。术后第2天开始灌胃给药,假手术组和模型组给予等体积生理盐水灌胃,每天1次。连续给药4周后采用心脏超声检测各组大鼠左室舒张末期内径(LVEDd)、左室收缩末期内径(LVEDs)、左室射血分数(LVEF)、左、右心室质量指数,检测血浆BNP水平。结果与假手术组比较,模型组LVEDd、LVEDs显著增加(P<0.05),LVEF明显下降(P<0.05),左、右心室质量指数明显增加(P<0.01),血浆BNP表达增加(P<0.05)。与模型组比较,黄芪皂苷低、高剂量组大鼠LVEDd、LVEDs减少(P<0.05),LVEF增加(P<0.05);左、右心室质量指数降低(P<0.01);血浆BNP水平降低(P<0.05)。结论黄芪皂苷可以降低血浆BNP水平,延缓心衰大鼠模型的心室重塑,改善心功能。Objective To observe the effect of astragaloside（ AST） on the ventricular remodeling and plasma brain natriuretic peptide（BNP） expression in rats with chronic heart failure. Methods The animal model of myocardial infarction was established by ligation of the left anterior descending coronary artery. Animals were randomly divided into 4 groups,including the model group,two different doses of AST groups（ 10 and 20 mg/kg） and the sham operation group. Intragastric administration of AST or physiological saline began day 2 after operation. After four weeks,LVEDd,LVEDs,LVEF and left/right ventricular mass index were detected by cardiac ultrasound. The level of plasma BNP was measured. Results Compared with the sham operation group,LVEDd and LVEDs were increased obviously（P〈0.05）,while LVEF was significantly decreased（ P〈0.05） in the model group. Meantime,left/right ventricular mass index and plasma BNP level were increased significantly in the model group. Compared with the model group,LVEDd and LVEDs were significantly decreased（ P〈0.05） ,but LVEDs was increased obviously（ P〈0.05） in the AST-treated group. Meantime,left/right ventricular mass index and plasma BNP level were decreased significantly. Conclusion AST can reduce BNP level in plasma,delay myocardial remodeling in rats with myocardial infarction and improve cardiac function.

关 键 词：黄芪皂苷 心室重塑 脑钠肽 心力衰竭 

分 类 号：R285.5[医药卫生—中药学]