我院非甾体抗炎药在治疗膝骨关节炎中的临床应用分析  

Utilization of non-steroidal anti-inflammatory drugs in the treatment of knee osteoarthritis in our hospital

作　　者：张建环[1] 朱群娣[2] 钟建明[1] 

机构地区：[1]广州中医药大学附属骨伤科医院药剂科,广东广州510240 [2]广东省中医院药剂科,广东广州510120

出　　处：《广东药学院学报》2014年第4期486-488,共3页Academic Journal of Guangdong College of Pharmacy

摘　　要：目的通过调查我院门诊治疗膝骨关节炎非甾体抗炎药的使用情况,对其疗效及安全性进行评估。方法随机选取我院门诊膝骨关节炎急性发作患者200例,分析非甾体抗炎药在膝骨关节炎治疗中的使用情况。结果我院门诊医师选用非甾体抗炎药主要包括传统的非甾体抗炎药和选择性COX-2抑制剂,使用频率分别为38.5%和61.5%,其有效率为分别为93.3%和95.7%,总有效率为94.5%。不良反应发生率分别为13.5%和6.5%。结论非甾体抗炎药在使用期间,不良反应发生率较高,医师应保持高度警惕性,严密监测全身各脏器的功能,以便及早发现问题,并给予积极有效的处理。Objective To investigate the application of non-steroidal anti-inflammatory drugs（ NSAIDs） in the treatment of knee osteoarthritis, and assess its efficacy and safety. Methods 200 cases with knee osteoarthritis in our hospital were randomly collected. The application of NSAIDs was analyzed. Results NSAIDs including conventional anti-inflammatory drugs and selective COX-2 inhibitors were used in outpatients, with usage rates of 38. 5% and 61. 5%, the effective rates of 93. 3% and 95. 7%, and the incidence of adverse reactions 13. 5% and 6. 5%, respectively. Conclusion It should be noticed that the incidence of adverse reactions is high in application of NSAIDs and the function of organs should be monitored carefully and treated reasonably.

关 键 词：非甾体抗炎药 安全性 膝骨关节炎 

分 类 号：R684.3[医药卫生—骨科学]