Dimensions of receptor-ligand complex and the optimal radius of endocytosed virus-like particle  

作　　者：Yan-Hui Liu Ying-Bing Chen Wei Mao Lin Hu Lin-Hong Deng Hou-Qiang XU 

机构地区：[1]Key Laboratory of Animal Genetics, Breeding and Reproduction in the Plateau Mountainous Region Ministry of Education, College of Animal Science, Guizhou University, Guiyang 550025, China [2]Soft Condensed Matter Laboratory, College of Science, Guizhou University, Guiyang 550025, China [3]State Key Laboratory of Theoretical Physics, Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 100190, China [4]Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou 213164, China [5]Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044, China

出　　处：《Frontiers of physics》2014年第4期519-522,共4页物理学前沿（英文版）

基　　金：Acknowledgements are made to the National Natural Science Foundation of China （Grant Nos. 11047022, 11204045, and 31360215）, the Research Foundation from Min- istry of Education of China （Grant No. 2012152）, Guizhou Provincial Tracking Key Program of Social Development （Grant Nos. SY20123089 and SZ20113069）, the Natural Science Foundation of Guizhou Province （Grant No. J20122166） and the Visiting Scholar Foundation from the Key Laboratory of Biorheological Science and Technology of Ministry of Education （Chongqing University）.

摘　　要：Recent experiments have pointed out that cellular uptake is strongly dependent on the physical dimensions of endocytosed nanoparticles and tile optimal radius of endocytosed virus-like particle coated by transferrin is around 50 nm. As the same time, the dimensions of receptor-ligand complex have strong effects on the size-dependent exclusion of proteins ill cell environments. Inspired by these experimental results, a continuum elastic model is constructed to resolve the relationship between the dinlensions of receptor-ligand complex and the optimal radius of endocytosed virus-like particle. These results demonstrate that the optimal radius of endocytosed virus-like particle depends on the dimensions of reeeptor-ligand complex and the dimension of receptor-ligand complex reduces the depletion zone.Recent experiments have pointed out that cellular uptake is strongly dependent on the physical dimensions of endocytosed nanoparticles and tile optimal radius of endocytosed virus-like particle coated by transferrin is around 50 nm. As the same time, the dimensions of receptor-ligand complex have strong effects on the size-dependent exclusion of proteins ill cell environments. Inspired by these experimental results, a continuum elastic model is constructed to resolve the relationship between the dinlensions of receptor-ligand complex and the optimal radius of endocytosed virus-like particle. These results demonstrate that the optimal radius of endocytosed virus-like particle depends on the dimensions of reeeptor-ligand complex and the dimension of receptor-ligand complex reduces the depletion zone.

关 键 词：cellular uptake depletion effects dimension of receptor-ligand complex elasticitytheory 

分 类 号：Q945.11[生物学—植物学] TB383[一般工业技术—材料科学与工程]