危重症应激性高血糖患者血清sRAGE水平及相关影响因素研究  

Study on the serum level of sRAGE and related factors in critically ill patients with stress hyperglycemia

作　　者：程燕子[1] 蔡德鸿[1] 钟吉文[2] 赵灵[2] 向阳[2] 

机构地区：[1]南方医科大学珠江医院,广州510282 [2]珠海市人民医院

出　　处：《内科急危重症杂志》2014年第4期237-238,250,共3页Journal of Critical Care In Internal Medicine

摘　　要：目的:观察可溶性糖基化终末产物受体(sRAGE)在危重症应激性高血糖患者中的表达,并探讨影响sRAGE表达的相关因素。方法:采用酶联免疫技术(ELISA法)测定57例危重症患者和25名健康体检者血清sRAGE及AGEs浓度,分析sRAGE与其它临床指标的相关性。结果:危重症患者血清sRAGE浓度及AGEs浓度均显著高于正常对照组(P<0.05);Pearson相关分析及Logistic回归分析显示血清sRAGE浓度与AGEs浓度呈显著正相关(P<0.01),但不是28d预后的影响因素(P>0.05)。结论:危重症患者血清sRAGE表达升高,可能与危重症患者糖基化终末产物水平升高有关,但不是影响危重症高血糖患者预后的因素。Objective：To observe the expression of serum level of soluble receptor for advanced glycation end products （sRAGE） in critically ill patients with stress hyperglycemia and its related influencing factors.Methods：Enzyme-linked immunosorbent assay （ELISA） was used to detect the serum levels of sRAGE and AGEs in 57 critically ill patients and 25 normal controls,other clinical indexes were also tested.Results：Serum levels of sRAGE and AGEs were significantly higher in critically ill patients than those in normal controls （P 〈 0.05）.Pearson correlation analysis showed serum level of sRAGE was positively correlated with the level of AGEs （P 〈 0.01）,but the regression analyses showed that the level of sRAGE was not the influencing factor of prognosis at 28 day （P 〉 0.05）.Conclusions：The level of sRAGE is significantly higher in critically ill patients and correlate with AGEs,but is not the influencing factor of prognosis in critically ill patients with stress hyperglycemia.

关 键 词：可溶性糖基化终末产物受体 糖基化终末产物 危重症 

分 类 号：R589.1[医药卫生—内分泌]