内脂素基因rs2058539位点多态性与血脂水平及冠心病易感性的关联研究  

Association of visfatin gene rs2058539 polymorphism with serum lipids and coronary heart disease

作　　者：饶进[1] 王刚[2] 何皓[1] 尹敏[1] 孙海光[1] 金建华[1] 余德宇 

机构地区：[1]广东省东莞市长安医院内科, 523843 [2] 南华大学附属第一医院心内科

出　　处：《临床内科杂志》2014年第7期454-456,共3页Journal of Clinical Internal Medicine

摘　　要：目的 探讨内脂素基因rs2058539位点多态性与血脂水平及冠心病的关系.方法 应用聚合酶链反应（PCR）测序技术在对168例冠心病患者和182例健康对照者内脂素基因rs2058539位点进行基因分型,并进行关联分析.结果 rs2058539位点C等位基因频率在冠心病组中为42.3％,显著性高于健康对照组的32.1％ （P =0.006）,冠心病组中CC基因型频率为19.6％,显著高于健康对照组的7.7％（P＜0.01）.在健康体检者中,CC＋ CA基因型组血清HDL-C水平显著低于AA基因型组（P＜0.05）.结论 内脂素基因rs2058539位点与中国汉族人群冠心病及血清HDL-C水平的遗传易感性相关联.Objective To study the association of visfatin gene rs2058539 polymorphism with se- rum lipids and coronary heart disease. Methods rs2058539 of visfatin gene of 168 coronary heart disease patients and 182 control subjects were genotyped by PCR-sequencing. Meanwhile,association analysis was performed between case and control group. Results The genotype of CC and allele frequencies of C at rs2058539 in coronary heart disease group（ 19.6% and 42.3% ） were significantly higher than that in control group（7.7% and 32.1% ,P =0.004 and P =0.006）. However,the serum HDL-C levels of CC/ CA genotype were significantly lower than that in AA genotype （ P = 0.03 ）. Conclusion rs2058539 in visfatin gene are both associated with coronary heart disease and serum HDL-C levels in Chinese Han pop- ulation.

关 键 词：冠心病 高密度脂蛋白胆固醇 内脂素 单核苷酸多态性 易感基因 

分 类 号：R541.4[医药卫生—心血管疾病]