替罗非班治疗急性冠脉综合征的临床效果和安全性评价  

Effect and safety of tirofiban in the treatment of acute coronary syndromes

作　　者：马素霞[1] 

机构地区：[1]商丘市第一人民医院心内科,河南省商丘476100

出　　处：《中国基层医药》2014年第17期2581-2582,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的：分析替罗非班治疗急性冠脉综合征的临床效果及安全性。方法急性冠脉综合征患者80例，按随机数字表法分为观察组和对照组，两组均给予阿司匹林、氯吡格雷、低分子肝素治疗，观察组在此基础上给予替罗非班静脉注射，对照组则给予安慰剂，比较两组临床效果。结果观察组30 d内终点事件发生率15．00％，显著低于对照组的30．00％（χ2＝4．56，P＜0．05）；观察组给药3 d后心电图示ST-T段下移程度及缺血导联数量分别为（0．30±0．43）mm、（2．1±2．5）个，均明显优于对照组的（0．67±0．73）mm、（3．4±2．5）个（t＝5．12、3．56，均P＜0．05）。结论阿司匹林、氯吡格雷、肝素联合替罗非班可有效改善患者临床症状，同时可降低心肌缺血等不良事件的发生率，值得临床推广。Objective To analyze the clinical efficacy and safety of tirofiban in the treatment of acute coronary syndrom.Methods 80 cases with acute coronary syndrome , were randomly divided into the observation group and control group ,two groups were given aspirin ,grey,low molecular weight heparin treatment ,the observation group was given based on the class for tirofiban intravenous injection , the control group was given a placebo , the clinical effect were compared between two groups .Results In the observation group ,30 d end point event rate of 15.00%,significantly lower than that of the control group 30.00%（χ2 =4.56,P〈0.05）;The observation group was administered 3 d after the electrocardiogram showed the degree of ST-T segment depression in lead and ischemia were （0.30 ±0.43）mm,（2.1 ±2.5）,was significantly better than that of the control group （0.67 ±0.73） mm,（3.4 ± 2.5）（t =5.12,3.56,all P 〈0.05）.Conclusion Aspirin,clopidogrel,heparin combined voith tirofiban can effectively improve the clinical symptoms of patients with myocardial ischemia , and can reduce the incidence of adverse events,which is worthy of clinical application .

关 键 词：替罗非班 冠状动脉疾病 治疗结果 

分 类 号：R541.4[医药卫生—心血管疾病]