指纹图谱段带总量统计矩法对黄连解毒汤提取过程中成分变化的研究  

Composition change in extraction process of Huanglian Jiedu Decoction by fingerprint division total statistical moment method

作　　者：杨岩涛[1,2,3,4] 吴春英[5] 吴德智[1] 唐宇[1] 刘文龙[1,2,3,4] 石继连[1,2,4] 贺福元[1,2,3,4] 

机构地区：[1]湖南中医药大学药学院,湖南长沙410208 [2]中药药性与药效国家中医药管理局重点实验室,湖南长沙410208 [3]湖南中医药大学现代中药制剂制备技术与评价实验室,湖南长沙410208 [4]湖南中医药大学中医药超分子机理与数理特征化实验室,湖南长沙410208 [5]湖南中医药大学管理与信息工程学院,湖南长沙410208

出　　处：《中草药》2014年第15期2157-2164,共8页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金项目(81173558;81270055);高等学校博士学科点基金博导类项目(20124323110002);湖南省自然科学基金项目(13JJ5032;11JJ2055);湖南省中医药科研计划项目(201494);湖南省"十二五"省级药学重点学科项目(1007)

摘　　要：目的建立中药复方提取过程中成分变化信息分析方法——指纹图谱段带总量统计矩法。方法运用指纹图谱段带统计矩法分析黄连解毒汤指纹图谱信息,阐述中药复方提取过程中成分变化情况。结果黄连解毒汤煎煮160 min后成分基本趋于稳定。黄连解毒汤合煎与单味药提取过程相比,某些成分被抑制,某些成分被促进,亦可能有新成分的出现。结论指纹图谱段带统计矩法可用于中药复方提取过程中成分变化信息及中药复方提取时间的研究。Objective To establish a new analytical method of ingredients transformation during the Chinese material medica（CMM） compound extraction： chromatographic fingerprints division total quantum statistical moment（CFDTQSM） method. Methods The expression was set up by CFDTQSM method in order to analyze the fingerprint information of Huanglian Jiedu Decoction（HJD）, and to explain the ingredients transformation during the CMM compound extraction. Results It has been concluded by studying the extracting solution of HJD that the ingredients were stabilized after decocting for 160 min. And compared with the extraction process of single herb, some ingredients are restrained in HJD, some are advanced and some new ingredients are produced. Conclusion The CFDTQSM method could be used to the study on the ingredients transformation during the CMM compound extraction, and the study on extraction time.

关 键 词：指纹图谱 段带 总量统计矩 统计矩原理 中药复方 黄连解毒汤 

分 类 号：R286.02[医药卫生—中药学]