正交试验优选加压酒制山茱萸炮制工艺  

Optimization of high pressure processing of Comus officinalis with wine by orthogonal test

作　　者：许甜甜[1] 聂松柳[1] 沈炳香[1] 吴德玲[2] 金传山[2] 

机构地区：[1]安徽医科大学附属六安医院药学部,安徽六安237005 [2]安徽中医药大学药学院,安徽省现代中药重点实验室,安徽合肥230031

出　　处：《中草药》2014年第16期2339-2343,共5页Chinese Traditional and Herbal Drugs

基　　金：国际合作项目(2011DFA31950)

摘　　要：目的优选加压酒制山茱萸炮制工艺。方法以山茱萸中马钱苷、莫诺苷、熊果酸、齐墩果酸的质量分数为评价指标,采用正交设计法考察加酒量、闷润时间、蒸制时间和蒸制温度对炮制工艺的影响,确定最佳山茱萸加压酒制工艺。结果最佳炮制工艺参数:加酒量为药材量的25%,闷制时间为30 min,蒸制时间为60 min,蒸制温度为115℃。山茱萸炮制品外观色泽为紫黑色有光泽,炮制品的质量稳定。结论结合山茱萸炮制品的质量及外观色泽,优选的加压炮制工艺能够节约时间,保证质量,是一种能够适用于山茱萸企业规模化生产的炮制方法。Objective To optimize the high pressure processing of Comus officinalis with wine. Methods The yield of loganin, morroniside, ursolic acid, and oleanolic acid in C. officinalis was served as indexes. The orthogonal design was used to investigate the effects of wine volume, moistening time, processing time, and processing temperature on the processing technology, so as to obtain the optimal high pressure processing of C. officinalis with wine. Results The best processing conditions were as follows： wine volume was 25% of medicinal herbs, moistening time was 30 min, processing time was 60 min, and processing temperature was 115℃. Conclusion Combining the product quality and appearance, the processing technology can save time and ensure the quality, which could lay a good foundation for the processing technology by enterprise scale production preparation of C. officinalis.

关 键 词：山茱萸 加压酒制工艺 炮制 正交设计 马钱苷 莫诺苷 熊果酸 齐墩果酸 

分 类 号：R283.1[医药卫生—中药学]