沐舒坦对急性肺损伤患者保护作用的研究  

Study of the Protective Effect of Ambroxol on Acute Lung Injury Patients

作　　者：郑鹏[1] 杨径[1] 申群喜[1] 

机构地区：[1]深圳市第二人民医院急诊科,广东深圳518029

出　　处：《华夏医学》2002年第3期285-287,共3页Acta Medicinae Sinica

摘　　要：目的 :探讨沐舒坦对急性肺损伤患者预后的影响 ,明确其是否有预防急性肺损伤 (Acute lung injury,ALI)进一步发展至急性呼吸窘迫综合征 (Acute respiratory distresssyndrome,ARDS)的作用。方法 :选择 54例病情程度基本相同的急性肺损伤患者作为研究对象 ,随机分为沐舒坦治疗组 (2 8例 )和常规治疗组 (2 6例 )。比较治疗 5d后两组患者动脉血气和呼吸功能改变的差异 ;比较两组患者的预后 ,包括 ARDS发生率、病死率、存活患者的住院时间。结果 :治疗5d后两组患者动脉血气和呼吸功能较治疗前均有明显改善 (P<0 .0 1 ) ,沐舒坦组比常规组改善更明显 ;沐舒坦组患者ARDS发生率 (1 4 .3% )、病死率 (3.6% )均低于常规组 (ARDS发生率 2 3.1 % ,病死率 7.7% ) (P<0 .0 1 ) ;沐舒坦组存活患者的住院时间 (1 4 .1± 7.6) d明显短于常规组 (1 9.4± 6.5) d(P<0 .0 1 )。结论 :沐舒坦对急性肺损伤有保护作用 ,可降低急性肺损伤患者 ARDS的发生率及病死率 。Objective:To explore the protective effect of ambroxol on acute lung injury(ALI) patients and preventive effect of production of acute respiratory distress syndrome(ARDS) in them.Methods:54 of ALI patients were enrolled in our study subject and randomly divided into two groups.One group was served as general treatment group,included 26 patients who received high frequency oscillatory ventilation(HFO),another was served as ambroxol treatment group included 28 patients who received ambroxol treatment with HFO.Indices of arterial blood gas analysis were compared between general group and ambroxol group after 5days' treatment.Morbidity of ARDS,mortality of patients,time of hospitalization were compared,too.Results:After the 5days' treatment the indices of arterial blood gas analysis and respiratory function were improved in ambroxol group and general treatment group.Furthermore,the degree of improvement of indices in ambroxol group was more than that in general treatment group( P <0.01).Morbidity of ARDS and mortality in ambroxol group were lower than that in general treatment group ( P <0.01).The time of hospitalization in ambroxol group was shorter than that in general treatment group, too ( P <0 01).Conclusion:Ambroxol has an obvious protective effect on ALI patients.It could decreas morbidity of ARDS,mortality of patients and the length of hospitalization.

关 键 词：沐舒坦 急性肺损伤 保护作用 病死率 住院时间 

分 类 号：R563[医药卫生—呼吸系统]