运动与氧化还原信号调控  

Exercise and Redox Signaling Regulation

作　　者：刘静[1] 龙建纲[1] 刘健康[1,2] 

机构地区：[1]西安交通大学生命科学与技术学院线粒体生物医学研究所、生物医学与信息工程教育部重点实验室,西安710049 [2]西安交通大学前沿科学技术研究院前沿生命科学研究所线粒体生物医学中心,西安710049

出　　处：《生理科学进展》2014年第4期263-266,共4页Progress in Physiological Sciences

基　　金：国家自然科学基金(31070740,31370844)资助课题

摘　　要：活性氧既是细胞内的信号分子,也是引起细胞氧化应激的主要分子。适当强度的运动促进生理水平活性氧的生成,增强机体抗氧化能力,有助于改善代谢、延缓衰老及相关疾病;而过度运动则会导致机体内大量活性氧的产生,造成运动疲劳甚至运动损伤。线粒体是产生活性氧及维护细胞氧化还原稳态的主要细胞器。合理补充线粒体营养素可以维护细胞氧化还原稳态,部分模拟运动的生理效应;同时,能够缓解过度运动引起的运动疲劳,有助于提升运动能力并改善运动损伤。ROS,identified as signaling molecules,are responsible for maintaining redox homeostasis in vivo. Appropriate exercise promotes the generation of physiological ROS,enhances the antioxidative potential,promotes exercise performance,and improves metabolism,as well as retards aging and related diseases; whereas overload exercise causes excess ROS,resulting in exercise-induced fatigue or even exercise-induced injury. Mitochondria are the main pool of ROS production and act as the key organelles in modulating intracellular redox homeostasis. Mitochondrial nutrients not only maintain physiological redox homeostasis,but also ameliorate oxidative stress and fatigue induced by overload exercise,eventually improving exercise performance and preventing /ameliorating exercise-induced injury.

关 键 词：运动 氧化还原稳态 氧化应激 线粒体营养素 活性氧 

分 类 号：R339[医药卫生—人体生理学]