复方丹参联合纳洛酮治疗小儿重症手足口病的疗效观察  

Clinical observation on treating serious HFMD children with compound Danshen plus naloxone

作　　者：祝伟[1] 张念陪[1] 高兵[1] 

机构地区：[1]郑州市第一人民医院,河南郑州450004

出　　处：《中医临床研究》2014年第22期67-68,共2页Clinical Journal Of Chinese Medicine

摘　　要：目的:探讨复方丹参联合纳洛酮治疗小儿重症手足口病的疗效。方法:将2009年3月-2013年8月收入郑州市第一人民医院小儿手足口病区的重症手足口病具有神经精神症状患儿120例随机分成治疗组和对照组各60例,对照组使用常规治疗(吸氧、20%甘露醇降颅压、抗感染、营养脑细胞、应用糖皮质激素、应用静注人免疫球蛋白等),治疗组在对照组基础上应用复方丹参联合纳洛酮治疗,观察两组的临床症状、体征变化及住院时间。结果:治疗组疗效优于对照组(P<0.05),患儿临床症状缓解及出院时间明显低于对照组,两组差异有统计学意义(P<0.01)。结论:复方丹参联合纳洛酮治疗治疗小儿重症手足口病疗程短,见效快,值得临床推广应用。Objective： To observe clinical efficacy of compound Danshen plus naloxone on children serious HFMD disease. Methods： 120 patients were randomly divided into two groups, 60 cases in each. The control group was given conventional therapy, including oxygen inhalation, 20%mannitol to reduce intracranial pressure, anti-infection, nutrition of brain cells, glucocorticoid and human immune globulin administration;the treatment was added compound Danshen plus naloxone more. Changes of clinical symptoms and signs, length of stay were recorded. Results：Clinical efficacy in the treatment was better than that in the control （P〈0.05）, duration of clinical symptomatic relieving and length of stay in the treatment were shorter than those in the control. The difference was statistically significant （P〈0.01）. Conclusion： Compound Danshen plus naloxone was effective on pediatric serious HFMD with short course and quick returns, and is worthy of clinical promotion.

关 键 词：复方丹参 纳洛酮 手足口病 儿童 临床疗效 

分 类 号：R512.5[医药卫生—内科学]