盐酸度洛西汀肠溶微丸的制备及体外释放度考察  

Preparation and in vitro Release of Duloxetine Hydrochloride Enteric Coated Pellets

作　　者：李旸[1] 廖祥茹[1] 谢向阳[1,2] 陈晨[1] 韩亮[1] 陈鹰[1] 

机构地区：[1]广州军区武汉总医院药剂科,武汉430070 [2]军事医学科学院毒物药物研究所

出　　处：《中国药师》2014年第8期1325-1328,共4页China Pharmacist

摘　　要：目的:制备盐酸度洛西汀肠溶微丸,并对其体外释放度进行考察。方法:采用流化床包衣法制备盐酸度洛西汀载药微丸,再用HPMC包隔离层衣,最后使用Eudragit L30D-55包肠溶衣,制成盐酸度洛西汀肠溶微丸,并采用f2相似因子法评价自制制剂和参比制剂在释放介质中的体外释放行为。结果:体外释放度试验显示,自制制剂和参比制剂f2相似因子值大于50,说明两种制剂体外释放行为相似。结论:制备的盐酸度洛西汀肠溶微丸的释药行为较好,有望应用于工业生产。Objective ： To prepare enteric coated pellets of duloxetine hydrochloride and investigate the in vitro drug release behav- ior. Methods： The pellets were prepared by fluid bed coating technology using HPMC as the isolation layer coating material and Eud- ragit L30D-55 as the enteric coating material. The in vitro release behavior of the reference and self-prepared pellets was investigated by f2 similar factor method. Results： The in vitro release property proved that the value off2 was more than 50, suggesting the release be- havior of the two preparations was similar. Conclusion： The release behavior of duloxetine hydrochloride enteric coated pellets is quite promising, which may be used in industrial production.

关 键 词：盐酸度洛西汀 肠溶微丸 体外释放 

分 类 号：R944.9[医药卫生—药剂学]