栀子苷降尿酸作用研究  

Study on Anti-hyperuricemia Effect of Geniposide

作　　者：孟兆青[1,2] 唐朝辉[2] 闫云霞[1] 丁岗[2] 萧伟[2] 杨中林[1] 

机构地区：[1]中国药科大学中药学院,南京210009 [2]江苏康缘药业股份有限公司/中药制药过程新技术国家重点实验室/江苏省企业院士工作站,连云港222001

出　　处：《世界科学技术-中医药现代化》2014年第7期1565-1568,共4页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：科学技术部国家重大新药创制项目(2013ZX09402203):现代中药创制集群与数字制药技术平台;负责人:王振中

摘　　要：目的:探讨栀子苷对高尿酸血症小鼠的影响。方法:用氧嗪酸钾连续7天灌胃造成小鼠高尿酸血症模型,同时每天灌胃栀子苷(50、100、200 mg·kg-1),检测小鼠血清尿酸(SUA)、尿尿酸(UUA)、肝脏黄嘌呤氧化酶活性(XOD)。结果:栀子苷中、高剂量能显著降低高尿酸血症小鼠血清尿酸水平(P<0.01)。结论:栀子苷可通过促进尿酸排泄降低高尿酸血症小鼠的血清尿酸水平。This article was aimed to study the effect of geniposide in hyperuricemia mice. Different doses （50, 100, 200 mg·kg-1） of geniposide were administrated to hyperuricemia mice induced by potassium oxonate by gavage for seven consecutive days. Then, serum uric acid （SUA）, urinary uric acid （UUA） and the hepatic xanthine oxidase activities （XOD） of mice were detected. The results showed that the middle- and high-dose groups of geniposide reduced the level of SUA significantly （P〈0.01）. It was concluded that geniposide can reduce the level of SUA in hyperuricemia mice by promoting UUA excretion.

关 键 词：栀子苷 高尿酸血症 尿酸 尿尿酸 肝脏黄嘌呤氧化酶活性 

分 类 号：R285.5[医药卫生—中药学]