慢性阻塞性肺疾病急性加重危险窗证候分布的临床调查研究  

Clinical Investigation on Distribution of Syndrome in AECOPD-RW

作　　者：张海龙[1,2] 李建生[2,3] 王海峰[1,2] 曹帆[4] 侯聪霞[5] 潘颖超[6] 张盼奎[1,2] 余学庆[1,2] 

机构地区：[1]河南中医学院第一附属医院,郑州450000 [2]呼吸疾病诊疗与新药研发河南省协同创新中心,郑州450008 [3]河南中医学院老年医学研究所,郑州450008 [4]河南省人民医院,郑州450003 [5]河南省胸科医院,郑州450008 [6]浙江中医药大学附属第二医院,杭州310005

出　　处：《世界科学技术-中医药现代化》2014年第7期1587-1592,共6页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家中医药管理局2011年中医药行业科研专项(201107002):早期慢性阻塞性肺疾病稳定期中医治疗方案与转化应用研究;负责人:李建生;国家中医药管理局2012年度国家中医临床研究基地业务建设科研专项(JDZX2012028):基于"AECOPD危险窗"的辨证序贯治疗方案的疗效评价;负责人:王海峰

摘　　要：目的:基于临床调查阐释慢性阻塞性肺疾病急性加重(AECOPD)危险窗证候分布规律并探讨病机转化。方法:收集8所医院AECOPD患者急性加重缓解后进入危险窗的中医证候学相关资料,建立数据库,运用SPSS 13.0进行统计分析。结果:本次调查结果显示,15个基础证候中以肺气虚证频率最高,其次是肾气虚证和痰湿证;14个复合证候中以肺肾气虚证和痰湿阻肺证出现频率最高;AECOPD危险窗临床常见证候有肺肾气虚兼痰湿阻肺、肺肾气虚、肺脾气虚兼痰湿阻肺、肺脾气虚、肺肾气阴两虚兼痰湿阻肺、肺肾气阴两虚、肺肾气虚兼痰瘀阻肺和肺肾气阴两虚兼痰瘀阻肺。结论:AECOPD危险窗常见证候以虚实夹杂为主,单纯虚证及单纯实证较少。This article was aimed to explain the distribution of syndrome and study the change of pathogenesis in patients of acute exacerbation of chronic obstructive pulmonary disease risk-window （AECOPD-RW） based on clinical investigation. The data of the traditional Chinese medicine （TCM） syndrome of patients diagnosed as AECOPD into AECOPD-RW were collected from 8 hospitals. The database was established. Data was analyzed with SPSS 13.0 software. The results showed that among 15 basic syndromes, the syndrome of lung-qi deficiency was with the highest frequency, which was followed by the syndrome of kidney-qi deficiency and syndrome of phlegm-dampness. Among 14 combined syndromes, the syndrome of lung-kidney qi deficiency and the syndrome of phlegm-dampness accumulated in the lung were with the highest frequency. The common syndromes of AECOPD-RW were the syndrome of lung-kidney qi deficiency combined with the syndrome of phlegm-dampness accumulated in the lung, the syndrome of lung-kidney qi deficiency, the syndrome of lung-spleen qi deficiency combined with the syndrome of phlegm-dampness accumulated in the lung, the syndrome of lungspleen qi deficiency, the syndrome of lung-kidney qi-yin deficiency combined with the syndrome of phlegm-dampness accumulated in the lung, the syndrome of lung-kidney qi-yin deficiency, the syndrome of lung-kidney qi deficiency combined with the syndrome of phlegm-stasis accumulated in the lung, and the syndrome of lung-kidney qi-yin deficiency combined with the syndrome of phlegm-stasis accumulated in the lung. It was concluded that the main common syndromes of AECOPD-RW was the mixture of deficiency and excess. There was relatively less pure deficiency and excess syndrome.

关 键 词：慢性阻塞性肺疾病 急性加重 危险窗 证候 

分 类 号：R259[医药卫生—中西医结合]