再生障碍性贫血T-bet/IFN-γ信号通路及中医研究进展  

Study on T-bet/IFN-γ Signal Transduction Pathway in Aplastic Anemia and Chinese Medicine Study Development

作　　者：张丰丰 赵宗江[1] 张新雪[1] 田晨[1] 吴志奎[2] 

机构地区：[1]北京中医药大学基础医学院,北京100029 [2]中国中医科学院广安门医院,北京100053

出　　处：《世界科学技术-中医药现代化》2014年第7期1642-1648,共7页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：科学技术部国家重点基础研究发展计划"973计划"项目(2010CB530406):基于"肾藏精"的脏象理论基础研究-从障碍性贫血探讨"肾生髓"理论的研究;总课题负责人:王拥军;子课题负责人:吴志奎

摘　　要：再生障碍性贫血(AA)是T淋巴细胞介导的自身免疫性疾病。AA的发病机制研究主要集中在免疫功能异常、造血干细胞损伤、造血微环境异常3个方面。近年来,AA免疫机制异常越来越受到中医药血液病研究者的关注。AA发病机制中细胞因子及相关的细胞内信号转导通路尤其复杂,其中T-bet/IFN-γ信号通路在AA发生发展过程中起着重要的作用。本文就T-bet/IFN-γ及其相关信号传导通路在AA中的作用做一综述。Aplastic anemia （AA） is a Tlymphocyte-mediated autoimmune disease. The research on AA was focused on three areas, which were the pathogenesis of immune dysfunction, hematopoietic stem cell damage and abnormal hematopoietic microenvironment. In recent years, more attentions have been paid on abnormal immune mechanisms in the blood. There are complex intracellular cytokine and signal transduction pathway of pathogenesis in AA. And T-bet/IFN-γ signaling pathway plays an important role in development and progression of AA. This article aimed to review T-bet/IFN-γ signaling pathways in AA.

关 键 词：再生障碍性贫血 免疫机制 T-bet/IFN-γ信号通路 研究进展 

分 类 号：R556.5[医药卫生—血液循环系统疾病]