2种方案治疗口服降糖药无效2型糖尿病的数据包络分析  

Data Envelopment Analysis of 2 Therapy Schemes in the Treatment of Type 2 Diabetes Which is Inefficient by Oral Hypoglycemic Agents

作　　者：陈进[1] 刘秀珍[1] 戴武[1] 李琪[1] 曹荣娟[1] 李俊峰[1] 高雷[1] 刘燕[1] 

机构地区：[1]合肥市第二人民医院药学部,合肥230031

出　　处：《中国药房》2014年第34期3169-3172,共4页China Pharmacy

摘　　要：目的:比较2种方案治疗口服降糖药无效2型糖尿病的药物经济学效果。方法:利用数据包络分析法,对预混胰岛素注射液联合二甲双胍片(A组,n=30)、甘精胰岛素注射液联合二甲双胍片(B组,n=28)2种方案治疗口服降糖药无效的2型糖尿病进行分析。在随访过程中根据血糖波动特点调整每位患者给药剂量。每位患者每3个月随访1次,共随访5次。结果:两组患者的临床疗效指标空腹血糖、餐后2 h血糖、糖化血红蛋白差异无统计学意义(P>0.05),质量调整生命年(QALYs)A组高于B组。结论:2种治疗方案均能将血糖控制在相对理想的范围内,但A方案治疗口服降糖药无效2型糖尿病的投入产出达到最优,B组投入偏高且临床疗效和QALYs有待提高。OBJECTIVE： To compare the pharmacoeconomic effects of 2 therapy schemes in the treatment of type 2 diabetes which is inefficient by oral hypoglycemic agents. METHODS： The data envelopment analysis （DEA） was adopted to analyze Premixed insulin injection combined with Metformin tablets （group A,n=30） and Glargine insulin injection combined with Metformin tablets （group B, n=28） in the treatment of type 2 diabetes which was inefficient by oral hypoglycemic agents. The drug dosage was adjusted for each patient according to the characteristics of blood glucose fluctuation during follow-up. Each patient was fol- lowed up once every 3 months, 5 times in total. RESULTS： There was no ＇statistical significance in FBG, PBG2h and HbA1c between 2 groups （P〉0.05） ; group A was higher than group B in QALYs. CONCLUSIONS： 2 therapy schemes can control the blood glucose in a relatively ideal range; nevertheless, input-output of group A achieves optimal level, and that of group B is in high level relatively and clinical efficacy and QALYs of groups need to be improved.

关 键 词：2型糖尿病 降糖药 预混胰岛素注射液 甘精胰岛素注射液 数据包络分析 

分 类 号：R977.15[医药卫生—药品] R956[医药卫生—药学]