细胞角蛋白19的表达对原发性肝癌术后的预后价值  

Prognostic value of expression of cytokeratin 19 to liver resection for primary hepatic carcinoma

作　　者：杨李军[1] 徐土炳[2] 

机构地区：[1]重庆市公共卫生医疗救治中心,400036 [2]中国人民解放军第一六医院普通外科,新疆乌鲁木齐836500

出　　处：《检验医学与临床》2014年第16期2199-2200,2202,共3页Laboratory Medicine and Clinic

基　　金：全军医学科技青年培育项目(13QNP023)

摘　　要：目的探讨细胞角蛋白19(K19)表达对原发性肝癌肝切除术的预后价值。方法对152例肝细胞肝癌(HCC)行手术切除肝组织的患者进行研究,采用免疫组化法评估其肝癌组织中CK19的表达。≥5%的肿瘤细胞中度以上的膜和(或)胞质的表达定义为CK19阳性。结果 CK19阴性的患者术后1年和5年总生存率分别为90.7%和80.4%;CK19阳性组术后1年和5年总生存率分别为66.7%和32.2%,差异具有统计学意义。结论对于原发性肝癌患者,肝癌组织中CK19的表达增加往往表现为手术预后较差。Objective To investigate prognostic value of expression of Cytokeratin （CK） 19 to liver resection for primary hepatic carcinoma .Methods One hundred and fifty two hepatocellular carcinoma （HCC） patients who underwent liver resections were studied .Immunohistochemistry was used to evaluate the expression of Cytokeratin 19 in cancerous tissues .CK19 positivity was defined as membranous and/or cytoplasmic expression in ≥5% of tumor cells with moderate or strong intensity .Results The overall survival （OS） rate of CK19- HCC patients at 1 and 5 years after resections were 90 .7% and 80 .4% ,respectively .OS rate of CK19＋ HCC patients at 1 and 5 years after resections were 66 .7% and 32 .2% ,respectively .The difference was significant （P〈0 .05） .Conclusion For the pri-mary liver cancer patients ,the increased expression of CK19 in cancerous tissues tends to show poor prognosis .

关 键 词：细胞角蛋白19 肝癌 肝切除术 预后 

分 类 号：R512.62[医药卫生—内科学]