柔肝化纤方联合腹水超滤浓缩回输术治疗肝硬化腹水40例临床观察  

Clinical observation of combination of Rouganhuaqian prescription and ascites ultrafiltration concentration doping technique on cirrhotic ascites

作　　者：黄晶晶[1] 黄鸿娜[1] 王振常[1] 毛德文[1] 潘哲[2] 

机构地区：[1]广西中医药大学第一附属医院肝病科,广西南宁530023 [2]广西中医药大学

出　　处：《河北中医》2014年第10期1492-1495,共4页Hebei Journal of Traditional Chinese Medicine

基　　金：广西中医药大学自然科学研究课题(编号:p2012042)

摘　　要：目的观察柔肝化纤方联合腹水超滤浓缩回输术治疗肝硬化腹水的临床疗效。方法将80例肝硬化腹水患者随机分为2组，对照组40例予常规治疗，治疗组40例在对照组治疗基础上应用柔肝化纤方联合腹水超滤浓缩回输术治疗。2组均7d为1个疗程，治疗4—8个疗程。比较2组疗效，观察2组治疗前后体质量、腹围、24h尿量、尿素氮、肌酐、血清白蛋白、Ⅲ型前胶原、Ⅳ型胶原、层粘连蛋白及透明质酸酶变化。结果2组总有效率比较差异有统计学意义（P〈0．05），治疗组疗效优于对照组。2组治疗后体质量、腹围均较本组治疗前降低（P〈0．05），24h尿量增加（P〈0．05）；治疗组治疗后24h尿量高于对照组（P〈0．05）。2组治疗后血清白蛋白均较本组治疗前升高（P〈0．05），且治疗组升高更明显（P〈0．05）。2组治疗前后Ⅲ型前胶原、Ⅳ型胶原、层粘连蛋白及透明质酸酶比较差异均无统计学意义（19〉0．05），2组治疗后组间比较差异无统计学意义（P〉0．05）。结论柔肝化纤方联合腹水超滤浓缩回输术治疗肝硬化腹水疗效显著，提高了患者的生活质量。Objective To observe the clinical effect of combination of Rouganhuaqian prescription and ascites uhrafihration concentration doping technique on cirrhotic ascites. Methods 80 patients with cirrhotic ascites were randomly divided into two groups. 40 patients in control group were treated by routine therapy. 40 cases in treatment group were treated by combination of Rouganhuaqian prescription and ascites uhrafihration concentration doping technique on the basis of control group treatment. The course was 7 days in two groups. After four to eight courses the changes of body weight, abdominal circumference,24 h urine output, blood urea nitrogen, creatinine, serum albumin, III procollagen, IV collagen,laminin and hyaluronidase before and after treatment were observed. Results There was significant difference between two groups on the total effective rate （ P 〈 0.05 ）. That of treatment group was superior to that of control group. The body weight, abdominal circumference after treatment were decreased as compared with those before treatment in two groups （ P 〈 0.05 ）. 24 h urine output was increased （ P 〈 0.05 ）. The increase of 24 h urine output in treatment group was more significant （ P 〈 0.05 ）. Conclusion Combination of Rouganhuaqian prescription and ascites uhrafiltration concentration doping technique on cirrhotic ascites, curative effect is distinct, it can improve the life quality of patients.

关 键 词：腹水 肝硬化 中西医结合疗法 剂型 

分 类 号：R442.5[医药卫生—诊断学] R575.205[医药卫生—临床医学]