卡贝缩宫素预防妊娠期高血压疾病妇女剖宫产产后出血效果分析  

Effect of Prophylactic Carbetocin in Prevention of Postpartum Hemorrhage Following Cesarean Delivery in Women with Hypertensive Disorder Complicating Pregnancy

作　　者：韩凌霄[1] 于芳[1] 侯海燕[1] 史海霞[1] 吴桃[1] 杨维平[1] 

机构地区：[1]武警后勤学院附属医院妇产科,天津300162

出　　处：《国际妇产科学杂志》2014年第4期423-425,共3页Journal of International Obstetrics and Gynecology

基　　金：天津市应用基础及前沿技术研究计划(11JCZDJC20000)

摘　　要：目的:探讨卡贝缩宫素对妊娠期高血压疾病妇女剖宫产宫缩乏力性产后出血的预防效果。方法:选择武警后勤学院附属医院产科32周后单胎剖宫产分娩的妊娠期高血压疾病产妇,随机分为2组进行前瞻性随机对照研究。其中治疗组(卡贝缩宫素组)90例,剖宫产时胎儿娩出后卡贝缩宫素100μg宫底肌内注射;对照组(缩宫素组)90例,胎儿娩出后缩宫素100μg宫底肌内注射,2组均同时予缩宫素20 IU持续静脉点滴。记录产后24 h内出血量、血压、胎儿体质量、评分、妊娠妇女心率的变化及药物不良反应。结果:治疗组产后24 h内出血量少于对照组,差异有统计学意义(P<0.05)。治疗组和对照组产后出血的发生率分别为14.4%和20.0%,差异无统计学意义(P>0.05)。2组新生儿出生体质量、1分钟Apgar评分、新生儿窒息、羊水性状比较差异无统计学意义(P>0.05)。治疗组未出现明显恶心呕吐症状。结论:卡贝缩宫素预防妊娠期高血压疾病妇女剖宫产产后出血比单用缩宫素效果更好,无明显不良反应。Objective：To explore carbetocin in the prevention of postpartum hemorrhage （PPH） following cesarean delivery in women with hypertensive disorder complicating pregnancy. Methods：Prospective randomized control study was carried out on single pregnancy with gestation more than 32 weeks following cesarean delivery. All the cases were randomized to receive either carbetocin （treatment group,n=90） or oxytocin （control group,n=90）. Following delivery of each baby,20 IU oxytocin was infusion and 100 microgram carbetocin（treatment group） and 100 microgram oxytocin（control group） were given as myometrium injection. 24 h blood volume of postpartum,blood pressure,birth weight,Apgar scores,maternal heart rate and drug adverse reaction were collected. Results：The estimated blood loss within 24 h in treatment group was significantly lower than control group （P〈0.05）. The incidence postpartum haemorrhage of treatment and control group had no difference （14.4%vs. 20.0%,P〉0.05）. There was no difference in birth weight,Apgar scores,neonatal asphyxia and amniotic fluid characteristics between the two groups （P〉0.05）. There was no significant syndrome of nausea and vomiting. Conclusions：Carbetocin makes better effect than common oxytocin on prevention of postpartum haemorrhage cesarean delivery in women with hypertensive disorder complicating pregnancy ,and no adverse complication was found.

关 键 词：催产素 高血压 妊娠性 产后出血 

分 类 号：R719.8[医药卫生—妇产科学]