嵌段聚合物修饰的金纳米粒子的制备及表征  

Preparation and characterization of gold nanoparticles stabilized by diblock copolymers

作　　者：翟翠萍[1] 陈霞[1] 李东风[1] 高青雨[1] 

机构地区：[1]河南大学化学化工学院,河南开封475004

出　　处：《化学研究与应用》2014年第8期1237-1242,共6页Chemical Research and Application

基　　金：国家自然科学基金项目(50273010)资助;河南省自然科学基金项目(132300410235)资助

摘　　要：通过RAFT合成聚(甲基丙烯酸缩水甘油酯)-b-聚(乙二醇甲基丙烯酸酯)嵌段共聚物(PGMA-bPMAPEG),再用半胱氨酸(Cys)使PGMA中的环氧基团开环,制备含有巯基的两亲水嵌段聚合物PMAPEG-bP(GMA-Cys)。并以其作为修饰剂,通过原位还原法使HAuCl4在NaBH4的还原下制备金/聚合物纳米复合粒子(Au@PMAPEG-b-P(GMA-Cys)NPs)。经FT-IR、UV-vis、TG、XRD、TEM和DLS表征,发现金纳米复合粒子呈均匀分散的球形,平均粒径约为10nm,在527nm处出现了金纳米粒子的表面等离子共振吸收峰,金约占总重量的49%。由于外层嵌段共聚物的修饰作用,金纳米复合粒子在室温下放置6个月未发生粒子间的聚集。The diblock copolymer of poly（2,3-epoxypropyl methacrylate glycidyl methacrylate）-b-poly（poly（ethylene glycol）meth-ylether methacrylate）（PGMA-b-PMAPEG）was prepared by reversible addition-fragmentation chain transfer（RAFT）polymeriza-tion. Then thiol-functionalized polymer PMAPEG-b-P（GMA-Cys）was synthesized by the reaction of cysteine（Cys）with the epoxy groups of PGMA. Furthermore,using MAPEG-b-P（GMA-Cys）as a modifier,Au@PMAPEG-b-P（GMA-Cys）NPs has been synthe-sized by in-situ reduction of HAuCl4 with sodium borohydride（ NaBH4 ） as a reductant. The gold nanocomposite particles were char-acterized by UV-visible（ UV-vis） ,fourier transform infrared spectroscopy（ FT-IR） ,thermal gravimetric analysis（ TGA） ,X-Ray dif-fraction（XRD）,transmission electron microscopy（TEM）and dynamic light scattering（DLS）,found that the gold nanocomposite particles were uniformly dispersed spherical and the average size was about 10nm. UV-visible spectra displayed that the surface plasma resonance absorption peak appeared at about 527nm for gold nanocomposite particles. The TGA curves indicated that the percentage of gold in the gold nanocomposite particles is 49%. The gold composite particles did not occur aggregation between parti-cles at room temperature over six months because the modification of the outer block copolymer.

关 键 词：嵌段聚合物 修饰剂 原位还原 金纳米粒子 制备 

分 类 号：O632.52[理学—高分子化学]