烯醇化酶与寄生虫感染  

Enolase and parasitic infection

作　　者：高玒[1] 余传信[1] 

机构地区：[1]江苏省血吸虫病防治研究所卫生部寄生虫病预防与控制技术重点实验室江苏省寄生虫病分子生物学重点实验室,无锡214064

出　　处：《中国血吸虫病防治杂志》2014年第4期445-448,共4页Chinese Journal of Schistosomiasis Control

基　　金：江苏省人事厅“333人才项目”基金;国家自然科学基金(30972581、81201316);江苏省自然科学基金(BK2008110、BK2012544);国家重大科技专项(2012ZX10004.220)

摘　　要：烯醇化酶是生物体中广泛存在的一种重要的糖酵解酶类,近来发现其还具有激活纤溶酶原的功能,参与寄生虫在宿主体内侵染和转移过程,并能下调宿主免疫功能,协助寄生虫逃避宿主的免疫攻击。本文总结当前对寄生虫烯醇化酶的研究进展,旨在探究其用于寄生虫病诊断、药物研发及疫苗靶标的可能性。Enolase is one kind of important glycolytic enzymes which widely exists in most organisms. A number of recent studies confirm that this enzyme has the functions of activating the plasminogen involving in the processes of infection and mi-gration of parasites reducing the immune function of the host as well as preventing parasites from the immune attack of the host. This paper reviews the current research advances in the parasite enolase and explores its potential for diagnosis drug develop-ment and vaccine target of parasitic diseases.

关 键 词：寄生虫 烯醇化酶 纤溶酶原受体 感染 免疫 

分 类 号：R38[医药卫生—医学寄生虫学]