N,N’-二环己基-N-山嵛酸酰脲体内外抗肿瘤作用  

Antitumor Effect of N,N-Dicyclohexyl-N-behenurea in Vitro and in Vivo

作　　者：陈虹[1] 刘全军[1] 廖乙媚 张云[2] 邝晓聪[3] 秦箐[1] 

机构地区：[1]广西医科大学药学院天然药物化学教研室,广西南宁530021 [2]广西医科大学附属肿瘤医院检验科,广西南宁530021 [3]广西医科大学基础医学院病理生理学教研室,广西南宁530021

出　　处：《广东化工》2014年第16期19-20,4,共3页Guangdong Chemical Industry

基　　金：板蓝根高级不饱和脂肪酸类似物的合成及免疫活性QSAR研究与活性化合物筛选

摘　　要：目的:观察N,N’-二环己基-N-山嵛酸酰脲的体内外抗肿瘤作用。方法:镜下观察N,N’-二环己基-N-山嵛酸酰脲体外对肿瘤细胞的影响。以小鼠S180腹水瘤细胞腹腔造模,ip给药,每天1次,至动物全部死亡,分别观察小鼠的生存时间和体重增长,计算生命延长率。结果:体外实验中,在200μg/mL以上对肿瘤细胞具有明显的抑制作用。体内给予N,N’-二环己基-N-山嵛酸酰脲50 mg/kg、5 mg/kg和0.5 mg/kg对S180腹水瘤小鼠的生命延长率分别为28.86%、25.37%和7.96%。结论:N,N’-二环己基-N-山嵛酸酰脲在体内外均具有明显的抗肿瘤作用。AIM： To investigate the antitum or effect of N,N-DicyclohexyI-N-behenurea in vitro and in vivo. METHODS： Observe N,N-Dicyclohexyl-N- behenurea on the growth of BEL-7404 and TCA-8113 in vitro. The ascitic-tumor model mice induced by S180 were ip given N,N-Dicyclohexyl-N-behenurea once daily until all mice dead. The effect of N,N-dicyclohexyl-N-behenurea on survival time, prolongation of time span, increase of weight and production of abdominal cavity tumor were studied respectively. RESULTS： In vitro, more than 200 μg/mL has an obvious effect on inhibition of BEL-7404 and TCA-8113. In vivo, N,N-Dicyclohexyl-N-behenurea 50 mg/kg, 5 mg/kg and 0.5 mg/kg significantly prolonged survival time of S180 ascitic-tumor mice, and the life prolongation rate was 28.86 %, 25.37 % and 7.96 % respectively. CONCLUSION： N,N-Dicyclohexyl-N-behenurea has significant antitumor action in vitro and in vivo.

关 键 词：N N'-二环己基-N-山嵛酸酰脲 抗肿瘤 生命延长率 腹水瘤 

分 类 号：TQ460.4[化学工程—制药化工]