乙酰水杨酸(阿司匹林)体外对流感病毒H1N1的抑制作用  

Acetylsalicylic Acid(aspirin) in Vitro Inhibition of Influenza Virus H1N1

作　　者：丁宁[1] 卢芯 郑丛龙[1] 韦淳巍 许梦亭 向敏[1] 林雨馨 

机构地区：[1]大连大学医学院,辽宁大连116622

出　　处：《大连大学学报》2014年第3期98-100,共3页Journal of Dalian University

基　　金：大连大学大学生创新创业训练计划项目(201311258017)

摘　　要：探讨乙酰水杨酸(Acetylsalicylic Acid)在体外对流感病毒H1N1的抑制作用。采用血球凝集试验、神经氨酸酶活性抑制试验和鸡胚接种法,观察AS对流感病毒H1N1的抑制作用。血球凝集试验可以看出,AS对流感病毒H1N1包膜表面的血凝素活性有一定的抑制作用,且作用较为显著;鸡胚培养法的结果显示,AS明显抑制了流感病毒H1N1在鸡胚内的增值,实验组血凝效价低于1:2,对照组血凝效价为1:512;神经氨酸酶活性抑制试验的结果显示,AS能够明显抑制流感病毒H1N1的神经氨酸酶活性。结果表明AS在体外对流感病毒H1N1有明显的抑制作用,其抑制机理可能与AS对流感病毒血凝素和神经氨酸酶活性抑制有关。To study the acetylsalicylic acid（AS） in vitro inhibition of influenza virus H1N1. Using methods of hemagglutination test, neuraminidase enzyme inhibition test and chicken embryo inoculation, the inhibition of influenza virus H1N1 was observed. Hemagglutination test results showed that AS inhibited activity of the H1N1 influenza virus hemagglutinin and the effect is more significant; embryo culture results showed, AS significantly inhibited H1N1 influenza virus in eggs value within the experimental group hemagglutination titer less than 1：2, the control group hemagglutination titer 1：512; neuraminidase enzyme inhibition test results showed, AS can inhibit the influenza virus H1N1 neuraminidase activity. All study showed that H1N1 influenza virus in vitro was significantly inhibited by AS, the mechanism is concern with AS inhibition of influenza virus hemagglutinin and neuraminidase inhibition of enzyme activity.

关 键 词：乙酰水杨酸 流感病毒H1N1 抑制作用 作用机理 

分 类 号：R373.13[医药卫生—病原生物学]