气相色谱法测定乳香风湿气雾剂中二甲苯麝香的残留量  

Determination of musk xylene residue in Ruxiang Fengshi aerosol by GC

作　　者：王琼[1] 高芳[1] 金红宇[1] 马双成[1] 

机构地区：[1]中国食品药品检定研究院,北京100050

出　　处：《药物分析杂志》2014年第8期1489-1491,共3页Chinese Journal of Pharmaceutical Analysis

基　　金：十二五"重大新药创制"专项课题"中药质量安全检测及风险控制平台"(课题编号2014ZX09304307-002)

摘　　要：目的：建立气相色谱法测定乳香风湿气雾剂中二甲苯麝香含量。方法：采用以交联5%苯基甲基聚合硅胶氧烷为固定相的毛细管柱,ECD检测;程序升温初始温度160℃,以6℃·min-1升至230℃,再以30℃·min-1升至300℃,保持3 min;进样口温度230℃,检测器温度300℃。结果：二甲苯麝香浓度在0.4~5.0μg·mL-1范围内线性关系良好,平均加样回收率（n=5）为96.2%,RSD为4.5%。结论：该方法简便、快速,结果准确可靠,可用于乳香风湿气雾剂中二甲苯麝香的限量检查。Objective： To establish the GC method for determination of musk xylene in Ruxiang Fengshi aerosol.Methods： Capillary column with 5% phenyl methyl siloxane polymeric silicone was adopted as the stationary phase,and the signals were detected with ECD. The temperature programing rose from 160 ℃ to 230 ℃ at a rate of6 ℃ ·min- 1,then to 300 ℃ at a rate of 30 ℃·min- 1,which lasted for 3 min in the end. The inlet temperature of the capillary column was 230 ℃,and the temperature of the detector was 300 ℃. Results： Musk xylene had a good linear relationship in the range of 0. 4- 5. 0 μg·mL- 1. The average recovery（ n = 5） was 96. 2% and RSD was4. 5%. Conclusion： This method is simple,rapid and accurate,with good reproducibility. It can be used for the limit test of musk xylene in Ruxiang Fengshi aerosol.

关 键 词：乳香风湿气雾剂 二甲苯麝香 酮麝香 气相色谱法 限量检查 

分 类 号：R917[医药卫生—药物分析学]