TPO-Ab与体外受精-胚胎移植结局的关系  

Influence of TPO-Ab on in vitro fertilization and embryo transfer ending

作　　者：王莉云[1] 靳隽[2] 王辉[2] 党小红[1] 

机构地区：[1]青海省人民医院生殖医学中心,西宁市810007 [2]新乡医学院,453003

出　　处：《实用医学杂志》2014年第16期2619-2622,共4页The Journal of Practical Medicine

摘　　要：目的:研究甲状腺过氧化物酶抗体(thyroid peroxidase-Ab,TPO-Ab)对体外受精-胚胎移植(in vitro fertilization and Embryo transfer,IVF-ET)结局的影响。方法:分析2011年3月至2013年10月期间在青海省人民医院生殖中心接受体外受精-胚胎移植患者共计378个助孕周期资料。甲状腺过氧化物酶抗体阳性且甲状腺功能正常患者69个周期作为研究组(A组),甲状腺过氧化物酶抗体阴性且甲状腺功能正常者309个周期作为对照组(B组)。结果 :TPO-Ab阳性组与对照组两组间IVF受精率(79.76%vs.84.08%),优质胚胎率(46.59%vs.54.49%),TPO-Ab阳性组明显低于TPO-Ab阴性组,差异有统计学意义(P<0.05);TPO-Ab阳性组的流产率(33.33%)明显高于TPO-Ab阴性组(16.11%),差异有统计学意义(P<0.05)。结论:甲状腺过氧化物酶抗体阳性可降低IVF受精率及优胚率、增加流产率对IVF-ET结局有不利影响。Objective To Study the effect of thyroid peroxidase-Ab （TPO-Ab） on in vitro fertilization and embryo transfer （IVF-ET） ending. Methods From March 2011 to October 2013, a total of 378 assisted reproduction cycles in Reproductive Medical Center of Qinghai Provincial People ’s Hospital were retrospectively analyzed in. Experiment group included 69 cycles from patients with positive thyroid peroxidase antibody and normal thyroid function and control group 309 cycles from those with negative thyroid peroxidase antibody and normal thyroid function. Results IVF fertility rate （79.76%） and high quality embryo rate （46.59%） in experiment group were significantly lower than those in control group （84.08%, 54.49% respectively） and the difference was statistically significant （P 〈 0.05）; abortion rate （33.33%） in experiment group was obviously higher than that in control group （16.11%）, which was statistically significant （P 〈 0.05）. Conclusion Positive thyroid peroxidase antibody exerts adverse effects on IVF-ET ending since TPO-Ab reduces IVF fertilization rate and high quality embryo rate and increases the rate of abortion.

关 键 词：TPO-AB 体外受精-胚胎移植 流产 妊娠 

分 类 号：R714.8[医药卫生—妇产科学]