N-二氯乙酰基-4-乙基-1,3-噁唑烷的合成工艺研究  

Synthesis of N-dichloroacetyl-4-ethyl-1,3-oxazolidine

作　　者：付蕾[1] 周媛媛[1] 贾力维[1] 张春晶[1] 于丹[1] 孟永海[1] 黄楠楠[1] 

机构地区：[1]黑龙江中医药大学药学院,黑龙江哈尔滨150040

出　　处：《广东化工》2014年第15期14-14,27,共2页Guangdong Chemical Industry

基　　金：黑龙江省教育科学"十二五"规划2012年度课题(省青年专项课题):药学专业有机化学实验创新教学体系研究(课题编号:GBD1212075)

摘　　要：以2-氨基-1-丁醇、多聚甲醛和二氯乙酰氯为原料,三乙胺作缚酸剂,合成了标题化合物.产品经红外光谱、核磁共振谱和元素分析进行结构表征,并确定合成的较优反应条件为：以三乙胺作缚酸剂,三氯甲烷作溶剂,反应温度为-3～3℃,搅拌时间2h,产率为72.63％.The title compound was synthesized from 2-Amino-l-butanol, paraformaldehyde, dichloroacetyl chloride, and triethylamine was used as an acid binding agent. The products were charactered by infrared spectrum （1R）, nuclear magnetic resonance spectrum （NMR）, and elementary analysis, the optimum conditions were obtained as following： triethylamine was used as acid binding agent, trichloromethane was used as solvent, the reaction temperature was -3-3 ℃, stirring time was 2 h, the yield was 7g.63 %.

关 键 词：N-二氯乙酰基噁唑烷 合成 表征 

分 类 号：TQ463.4[化学工程—制药化工]