应用OCT研究NDR糖尿病患者视网膜改变  

Detection of early diabetic change with optical coherence tomography in diabetes mellitus patients without retinopathy

作　　者：李言[1] 张仲臣[1] 

机构地区：[1]航天中心医院眼科,北京100049

出　　处：《世界最新医学信息文摘》2014年第24期6-7,共2页World Latest Medicine Information Electronic Version

摘　　要：目的：应用光学相干断层扫描成像（OCT）观察正常人和无糖尿病视网膜病变（NDR）的糖尿病（DM）患者黄斑区视网膜厚度（RT）和视盘周围神经纤维层（RNFL）厚度的改变。方法对照组和NDR组各40只眼，采用OCT测量黄斑区RT和视神经RNFL，记录黄斑部9个分区（A1～A9）RT以及中心凹最低处视网膜厚度（A0）和视盘周围四个区域（颞侧、上方，鼻侧，下方）的RNFL。结果黄斑区RT对比，A3和A5区差异有统计学意义；视盘RNFL对比，上方和颞侧差异具有统计学意义。结论本研究发现NDR糖尿病患者眼底可能存在神经退行性病变，此方法可尽早发现视网膜的损害，为疾病早期诊断、发病机制研究及指导治疗提供帮助。Objective To detect the change of macular retinal thickness （RT）and retinal nerve fi bre layer （RNFL） thickness in normal subjects and type 2 diabetes patients with no diabetic retinopathy using OCT.Methods Forty eyes of patients with NDR were enrolled. While eyes of normal population （n=40） were also examined. The retinal and RNFL thickness were both measured in two groups by OCT. The RT in A1-A9 areas, the thickness in central fovea and RNFL in the peripheral area （temporal, superior, nasal and inferior） of the macula were all calculated and compared with healthy controls.Results Comparing with the normal eyes, retinal thickness signifi cantly decreased in A3 and A5 and RNFL thickness signifi cantly decreased in the superior and temporal in NDR group.Conclusion This study indicates that there may be a neurodegenerative disease in retinal fundus of diabetic patients. OCT checking could provide help for the early diagnosis, pathogenesis research and treatment of this disease.

关 键 词：光学相干断层扫描 糖尿病 视网膜神经纤维层厚度 视网膜厚度 

分 类 号：R587.1[医药卫生—内分泌]