石墨炉原子吸收光谱法测定福沙吡坦中痕量钯  

Determination of Trace Palladium in Fosaprepitant by Graphite Furnace Atomic Absorption Spectrometry

作　　者：颜琳琦 李樱红 郭旺明[2] 

机构地区：[1]浙江省食品药品检验研究院,浙江杭州310004 [2]杭州九源基因工程有限公司,浙江杭州310018

出　　处：《中国药业》2014年第16期53-54,共2页China Pharmaceuticals

摘　　要：目的 建立福沙吡坦中痕量钯的测定方法,并验证除钯工艺的效果。方法 采用微波消解法处理样品,石墨炉原子吸收分光光度法测定福沙吡坦中钯的残留量。结果 钯质量浓度在5~50μg/L范围内与吸光度线性关系良好（r=0.999 9）,检出限为1.68μg/L,样品中的最低检出浓度为0.22μg/g;方法平均回收率为100.82%,RSD=3.34%（n=9）。结论 采用该方法测定福沙吡坦中钯的残留量,方法灵敏、准确、可靠,为药品的质量控制提供了依据。Objective To establish a method for the determination of trace palladium（Pd） in fosaprepitant and to verify the effect of the Pd- removing process. Methods The microwave digesting method was adopted to process the sample, the Pd residual amount in fosaprepitant was detected by the graphite furnace atomic absorption spectrometry（AAS） method. Results The mass concentration of Pd within the concentration range of 5-50 μg/L showed the good linear relation with the absorbance（r=0. 999 9）. The limit of detection （LOD） was 1.68 μg/L, the minimal detectable concentration in the sample was 0.22 μg/g and the average recovery rate was 100.82%, RSD =3.34% （n =9）. Conclusion Adopting this method is sensitive, accurate and reliable for detecting the Pd residual amount in fosaprepitant and provides the basis for the quality control of this drug.

关 键 词：石墨炉原子吸收分光光度法 钯 福沙吡坦 

分 类 号：R927.1[医药卫生—药学] R975.4