具有广泛抗病毒活性的SAMHD1蛋白的研究进展  

Progresses on the SAMHD1 Proteins with Broad Antiviral Effect

作　　者：杨光文[1] 张金阳[1] 夏雪山[1] 

机构地区：[1]昆明理工大学生命科学与技术学院,中国云南昆明650500

出　　处：《生命科学研究》2014年第4期367-371,共5页Life Science Research

基　　金：国家自然科学基金资助项目(81260248;81360247);国家科技支撑计划项目(2012BAI39B01;2011BAI15B01-21);云南省科技创新平台建设计划资助(2012DA002)

摘　　要：SAMHD1蛋白是2011年首次被认定为一种独特的天然抗病毒因子,它主要在树突状细胞、巨噬细胞等髓系细胞中表达。它通过降解细胞内dNTPs的水平,使细胞内的dNTPs的水平低于病毒复制所需的水平,从而抑制髓系细胞中反转录病毒和DNA病毒的复制。HIV-2产生的病毒蛋白X(Vpx)可将泛素连接酶与SAMHD1相结合,使SAMHD1分子最后被蛋白酶体降解。最近还发现SAMHD1蛋白活性受多种因子影响,具有调节肿瘤细胞中LINE-1活性的功能。结合最新研究成果对SAMHD1的结构、功能、抗病毒机制以及影响因子进行综述。As a unique naturally anti-viral factor, SAMHD1 was firstly identified in 2011. It has been reported to express in myeloid-lineage monocytes, such as dendritic cell and macrophages. SAMHD1 could inhibit the replication of anti-retroviral and DNA virus in myeloid cells by degrading intracellular dNTPs levels to that below the level required for viral replication. After SAMHD1 combined with ubiquitin ligase complex via Viral protein X（Vpx） of HIV-2, it was degraded by the proteasome. Recently, it has been found that the activity of SAMHD1 might be affected by a variety of factors and the activity of regulating LINE-1 in tumor cell was identified. According to the latest studies, the structure and functions of SAMHD1, and antiviral mechanisms and impact factors of SAMHD1 were summarized.

关 键 词：SAMHD1蛋白 HIV限制因子 影响因子 抗病毒机制 

分 类 号：Q932[生物学—微生物学]